Department of Internal Medicine, Rheumatology and Clinical Immunology, Faculty in Katowice, Medical University of Silesia, 40-635 Katowice, Poland.
Department of Haematology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia.
Int J Mol Sci. 2020 Mar 18;21(6):2076. doi: 10.3390/ijms21062076.
MicroRNAs (miRNAs) are single-stranded, endogenous RNA molecules that play a significant role in the regulation of gene expression as well as cell development, differentiation, and function. Recent data suggest that these small molecules are responsible for the regulation of immune responses. Therefore, they may act as potent modulators of the immune system and play an important role in the development of several autoimmune diseases. Antiphospholipid syndrome (APS) is an autoimmune systemic disease characterized by venous and/or arterial thromboses and/or recurrent fetal losses in the presence of antiphospholipid antibodies (aPLs). Several lines of evidence suggest that like other autoimmune disorders, miRNAs are deeply involved in the pathogenesis of APS, interacting with the function of innate and adaptive immune responses. In this review, we characterize miRNAs in the light of having a functional role in the immune system and autoimmune responses focusing on APS. In addition, we also discuss miRNAs as potential biomarkers and target molecules in treating APS.
微小 RNA（miRNAs）是单链、内源性 RNA 分子，在基因表达调控以及细胞发育、分化和功能中发挥重要作用。最近的数据表明，这些小分子负责调节免疫反应。因此，它们可能作为免疫系统的有效调节剂，在几种自身免疫性疾病的发展中发挥重要作用。抗磷脂综合征（APS）是一种自身免疫性系统性疾病，其特征是存在抗磷脂抗体（aPL）时静脉和/或动脉血栓形成和/或反复胎儿丢失。有几条证据表明，与其他自身免疫性疾病一样，miRNAs 深度参与 APS 的发病机制，与先天和适应性免疫反应的功能相互作用。在这篇综述中，我们根据在免疫系统和自身免疫反应中具有功能作用的特点来描述 miRNAs，重点关注 APS。此外，我们还讨论了 miRNAs 作为治疗 APS 的潜在生物标志物和靶分子。
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