Fabbri A, Tacchella A, Belli M L, Losurdo G
2nd Clinic for Infectious Diseases, University of Genova, Italy.
Chemioterapia. 1988 Dec;7(6):378-81.
The Authors report microbiological data on the inhibitory activity of cephalothin, cefamandole, FCE 22101, gentamicin, netilmicin, amikacin, rifampicin, clindamycin, josamycin, ofloxacin, ciprofloxacin, vancomycin and teicoplanin against 165 clinically isolated Staphylococcus aureus strains. 34 of the study strains, i.e. 20.6%, were methicillin- and oxacillin-resistant. The activity of the tested drugs was good; the presence of nosocomial strains resistant to rifampicin (12.13%), clindamycin (13.94%), josamycin (18.2%), ofloxacin (4.85%), ciprofloxacin (12.7%), gentamicin (27.3%), amikacin (9.7%), netilmicin (7.9%) was noted. The Authors emphasize the good inhibitory activity of tested beta-lactam drugs against methicillin-sensitive Staphylococci, but also the limits of these drugs against methicillin-resistant strains. The activity of vancomycin and teicoplanin on all study strains was very good.
作者报告了头孢噻吩、头孢孟多、FCE 22101、庆大霉素、奈替米星、阿米卡星、利福平、克林霉素、交沙霉素、氧氟沙星、环丙沙星、万古霉素和替考拉宁对165株临床分离金黄色葡萄球菌菌株的抑菌活性微生物学数据。研究菌株中有34株，即20.6%，对甲氧西林和苯唑西林耐药。受试药物的活性良好；注意到存在对利福平（12.13%）、克林霉素（13.94%）、交沙霉素（18.2%）、氧氟沙星（4.85%）、环丙沙星（12.7%）、庆大霉素（27.3%）、阿米卡星（9.7%）、奈替米星（7.9%）耐药的医院菌株。作者强调受试β-内酰胺类药物对甲氧西林敏感葡萄球菌具有良好的抑菌活性，但也指出了这些药物对甲氧西林耐药菌株的局限性。万古霉素和替考拉宁对所有研究菌株的活性都非常好。
