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职业性接触浸有环氧树脂的碳纤维和评估其可呼吸性。

Occupational exposure to carbon fibers impregnated with epoxy resins and evaluation of their respirability.

机构信息

Interdisciplinary Department of Medicine, Section of Occupational Medicine, University of Bari, Bari, Italy.

Department of Earth and Geo-Environmental Sciences, University of Bari, Bari, Italy.

出版信息

Inhal Toxicol. 2020 Feb;32(2):63-67. doi: 10.1080/08958378.2020.1735582. Epub 2020 Mar 20.

Abstract

The study aims to investigate occupational exposure to carbon fibers impregnated with epoxy resins (carbon fiber reinforced [CFR]) in workers at an airplane fuselage section construction plant, by environmental and biological monitoring. Determination of airborne CFR was done by environmental sampling with active samplers, 11 of which were stationary and 19 personal samplings. The subsequent analyses were performed in the scanning electron microscope fitted with an X-ray microanalysis system (SEM-EDXA). Biological monitoring was carried out by determining CFR in exhaled breath condensate (EBC) collected from 19 male workers who wore personal environmental samplers (exposed workers) and from 10 male workers at the same factory who had no occupational exposure to CFR (internal controls). CFR analysis was done by SEM, applying the method used for determining asbestos fibers in aqueous samples. The airborne CFR concentrations were found to be significantly higher ( = 0.03) at personal samplings (median value 7.01 ff/L, range 1.24-11.16 ff/L) than stationary samplings (median value 1.93 ff/L, range 0.55-10.09 ff/L). The aerodynamic diameters calculated starting from the length and geometric diameter of the sampled CFRs were always higher than 20 µm. CFR was not found in any of the EBC samples collected from the exposed workers and controls. Despite the evidence of occupational exposure to low concentrations of CFR, the absence of such fibers in the EBC in the exposed workers confirms their non-respirability, as expected based on their aerodynamic diameter.

摘要

本研究旨在通过环境和生物监测,调查飞机机身段制造工厂工人接触环氧树脂浸渍碳纤维(碳纤维增强复合材料 [CFR])的职业暴露情况。通过使用主动采样器进行环境采样来确定空气中 CFR 的含量,其中 11 个为固定采样器,19 个为个人采样器。随后的分析在配备 X 射线微分析系统(扫描电子显微镜-EDXA)的扫描电子显微镜下进行。通过对佩戴个人环境采样器的 19 名男性工人(暴露工人)和来自同一工厂的 10 名无 CFR 职业暴露的男性工人(内部对照)呼出的呼吸冷凝物(EBC)中 CFR 进行测定,进行生物监测。CFR 分析通过 SEM 进行,采用测定水中石棉纤维的方法。发现个人采样(中位数 7.01 ff/L,范围 1.24-11.16 ff/L)的空气中 CFR 浓度明显高于固定采样(中位数 1.93 ff/L,范围 0.55-10.09 ff/L)(= 0.03)。从采样 CFR 的长度和几何直径计算得出的空气动力学直径始终高于 20 µm。从暴露工人和对照组收集的 EBC 样本中均未发现 CFR。尽管有证据表明工人接触低浓度的 CFR,但暴露工人的 EBC 中未发现此类纤维,这证实了它们的不可呼吸性,这与基于空气动力学直径的预期一致。

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