Krowka J F, Stites D P, Moss A R, Casavant C H, Carlson J R, Chermann J C, Barre-Sinoussi F, Rodgers R P, Bacchetti P, McHugh T M
Department of Laboratory Medicine, University of California, San Francisco 94143.
Diagn Clin Immunol. 1988;5(6):381-7.
Serum and leukocytes from a cohort of homosexual males were analyzed to determine the interrelationships of antibodies to human immunodeficiency virus (HIV), serum HIV antigen levels, and phenotypical differences in lymphocyte subpopulations of HIV antibody-positive (HIV Ab+) and HIV antibody-negative (HIV Ab-) homosexual males. Significant reductions were observed in the percentages of B lymphocytes, CD4+ and CD4+ kappa lambda- T lymphocytes and the CD4+/CD8+ ratios of HIV Ab+ homosexual males in comparison to HIV Ab- homosexual males. Significant increases were observed in the percentages of CD8+, CD8+ CD11b-, CD8+ kappa lambda-, CD8+ DR+, CD8+Leu7+, and Leu7+ lymphocytes of HIV Ab+ study subjects. Statistical analysis revealed that among the immunological variables tested, decreases in the CD4+/CD8+ ratio and in the percentage of CD4+ kappa lambda- lymphocytes showed the strongest associations with HIV-sero-positivity in asymptomatic homosexual males. Only 44 (16.5%) of 267 HIV Ab+ homosexual males had detectable levels of HIV antigen (HIV Ag) in their serum. The percentages of CD4+ or CD4+ kappa lambda- lymphocytes and the CD4+/CD8+ ratios of HIV Ab+ males differed significantly between HIV Ag-positive (HIV Ag+) and--negative (HIV Ag-) homosexual males. These variables, however, did not correlate well with HIV Ag levels,indicating that no clear associations can be drawn between levels of HIV antigen and lymphocyte subset abnormalities of HIV-infected individuals.
对一组同性恋男性的血清和白细胞进行了分析，以确定人类免疫缺陷病毒（HIV）抗体、血清HIV抗原水平以及HIV抗体阳性（HIV Ab+）和HIV抗体阴性（HIV Ab-）同性恋男性淋巴细胞亚群的表型差异之间的相互关系。与HIV Ab-同性恋男性相比，HIV Ab+同性恋男性的B淋巴细胞、CD4+和CD4+κλ-T淋巴细胞百分比以及CD4+/CD8+比值显著降低。HIV Ab+研究对象的CD8+、CD8+ CD11b-、CD8+κλ-、CD8+ DR+、CD8+Leu7+和Leu7+淋巴细胞百分比显著增加。统计分析显示，在测试的免疫变量中，CD4+/CD8+比值和CD4+κλ-淋巴细胞百分比的降低与无症状同性恋男性的HIV血清阳性呈最强关联。267名HIV Ab+同性恋男性中只有44名（16.5%）血清中可检测到HIV抗原（HIV Ag）水平。HIV Ag阳性（HIV Ag+）和阴性（HIV Ag-）同性恋男性中，HIV Ab+男性的CD4+或CD4+κλ-淋巴细胞百分比以及CD4+/CD8+比值存在显著差异。然而，这些变量与HIV Ag水平的相关性不佳，表明HIV感染个体的HIV抗原水平与淋巴细胞亚群异常之间无法得出明确的关联。
