展示人类 PLD。
Illustrating human PLD.
机构信息
Department of Biochemistry and Molecular Biology, and Center for Membrane Biology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
出版信息
Nat Chem Biol. 2020 Apr;16(4):364-365. doi: 10.1038/s41589-020-0503-3.
Abstract
Phospholipase D (PLD) regulates various cellular functions through the signaling lipid phosphatidic acid (PA). New crystal structures of human PLD1 and PLD2 reveal catalytic mechanism, inhibitor binding, and regulation, enabling future structure-based inhibitor design and functional studies of PLD.
摘要
磷脂酶 D (PLD) 通过信号脂质磷脂酸 (PA) 调节各种细胞功能。人源 PLD1 和 PLD2 的新晶体结构揭示了催化机制、抑制剂结合和调控，为未来基于结构的抑制剂设计和 PLD 功能研究提供了基础。
相似文献
1
Illustrating human PLD.展示人类 PLD。
Nat Chem Biol. 2020 Apr;16(4):364-365. doi: 10.1038/s41589-020-0503-3.
2
Role of protein kinase C alpha, Arf, and cytoplasmic calcium transients in phospholipase D activation by sodium fluoride in osteoblast-like cells.蛋白激酶Cα、Arf和细胞质钙瞬变在成骨样细胞中氟化钠激活磷脂酶D过程中的作用
J Bone Miner Res. 1996 Nov;11(11):1655-65. doi: 10.1002/jbmr.5650111109.
3
Overexpression of myristoylated alanine-rich C-kinase substrate enhances activation of phospholipase D by protein kinase C in SK-N-MC human neuroblastoma cells.肉豆蔻酰化富含丙氨酸的蛋白激酶C底物的过表达增强了蛋白激酶C在人神经母细胞瘤SK-N-MC细胞中对磷脂酶D的激活作用。
Biochem J. 1998 Jun 1;332 ( Pt 2)(Pt 2):321-7. doi: 10.1042/bj3320321.
4
Two uncommon phospholipase D isoenzymes from poppy seedlings (Papaver somniferum L.).来自罂粟幼苗（Papaver somniferum L.）的两种不常见的磷脂酶D同工酶。
Biochim Biophys Acta. 2003 Mar 17;1631(2):153-9. doi: 10.1016/s1388-1981(02)00362-1.
5
Regulation of membrane-bound phospholipase D by protein kinase C in HL60 cells. Synergistic action of small GTP-binding protein RhoA.蛋白激酶C对HL60细胞中膜结合型磷脂酶D的调控。小GTP结合蛋白RhoA的协同作用。
J Biol Chem. 1996 Feb 23;271(8):4366-72. doi: 10.1074/jbc.271.8.4366.
6
Tyrosine kinase-regulated small GTPase translocation and the activation of phospholipase D in HL60 granulocytes.酪氨酸激酶调节的小GTP酶易位及HL60粒细胞中磷脂酶D的激活
J Leukoc Biol. 1999 Dec;66(6):1021-30. doi: 10.1002/jlb.66.6.1021.
7
Phospholipase D in human platelets: presence of isoenzymes and participation of autocrine stimulation during thrombin activation.人血小板中的磷脂酶D：同工酶的存在及凝血酶激活过程中自分泌刺激的参与。
Platelets. 2008 May;19(3):211-24. doi: 10.1080/09537100701777329.
8
Differential phospholipase D activation by bradykinin and sphingosine 1-phosphate in NIH 3T3 fibroblasts overexpressing gelsolin.在过表达凝溶胶蛋白的NIH 3T3成纤维细胞中缓激肽和1-磷酸鞘氨醇对磷脂酶D的差异性激活作用
J Biol Chem. 1999 Sep 24;274(39):27385-91. doi: 10.1074/jbc.274.39.27385.
9
1,25-dihydroxyvitamin D3 but not TPA activates PLD in Caco-2 cells via pp60(c-src) and RhoA.1,25-二羟基维生素D3而非佛波酯通过pp60（c-src）和RhoA激活Caco-2细胞中的磷脂酶D。
Am J Physiol. 1999 Apr;276(4 Pt 1):G1005-15. doi: 10.1152/ajpgi.1999.276.4.g1005.
10
The PGE2-induced inhibition of the PLD activation pathway stimulated by fMLP in human neutrophils is mediated by PKA at the PI3-Kgamma level.前列腺素E2（PGE2）对甲酰甲硫氨酸-亮氨酸-苯丙氨酸（fMLP）刺激的人中性粒细胞中磷脂酶D（PLD）激活途径的抑制作用是由蛋白激酶A（PKA）在磷脂酰肌醇-3激酶γ（PI3-Kγ）水平介导的。
Biochem Pharmacol. 2007 Sep 1;74(5):730-41. doi: 10.1016/j.bcp.2007.06.013. Epub 2007 Jun 17.
引用本文的文献
1
Coupling Lipid Nanoparticle Structure and Automated Single-Particle Composition Analysis to Design Phospholipase-Responsive Nanocarriers.通过将脂质纳米粒子结构与自动化单颗粒组成分析相结合来设计磷脂酶响应性纳米载体。
Adv Mater. 2022 Jul;34(26):e2200839. doi: 10.1002/adma.202200839. Epub 2022 May 18.
2
PLD1 promotes reactive oxygen species production in vascular smooth muscle cells and injury-induced neointima formation.PLD1 促进血管平滑肌细胞内活性氧的产生和损伤诱导的新生内膜形成。
Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Jan;1867(1):159062. doi: 10.1016/j.bbalip.2021.159062. Epub 2021 Oct 2.
本文引用的文献
1
Crystal structure of human PLD1 provides insight into activation by PI(4,5)P and RhoA.人 PLD1 的晶体结构提供了对 PI(4,5)P 和 RhoA 激活的深入了解。
Nat Chem Biol. 2020 Apr;16(4):400-407. doi: 10.1038/s41589-020-0499-8. Epub 2020 Mar 16.
2
Human PLD structures enable drug design and characterization of isoenzyme selectivity.人源 PLD 结构使药物设计和同工酶选择性的特征分析成为可能。
Nat Chem Biol. 2020 Apr;16(4):391-399. doi: 10.1038/s41589-019-0458-4. Epub 2020 Feb 10.
Zotero 插件