Department of Clinical Neurosciences, Hotchkiss Brain Institute, Mathison Mental Health Centre and Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Canada.
Department of Experimental Medicine, Section of Human Physiology and Centro Polifunzionale di Scienze Motorie, University of Genova, Genova, Italy.
Mov Disord. 2020 Jun;35(6):1067-1071. doi: 10.1002/mds.28017. Epub 2020 Mar 21.
The ability to predict temporal outcome of body movement is abnormal in idiopathic dystonia and can be altered by cerebellar neuromodulation. Tremor in cervical dystonia might be associated with performance on motion perception tasks.
A total of 15 cervical dystonia patients with and 14 without tremor and 15 age-matched healthy participants estimated the termination of videos showing different movements (handwriting a sentence, ball reaching a target) after these were darkened at different time intervals.
Cervical dystonia patients with tremor exhibited greater absolute timing error across all intervals of the hand motion task (group × task interaction effect, F = 4.57; P = 0.016). The percentage of responses in anticipation for both motion tasks did not differ across groups, suggesting lack of timing error directionality.
Temporal processing of perceived motion in cervical dystonia is associated with the presence of tremor. Cortico-cerebellar network abnormalities in cervical dystonia might account for motion processing changes in these patients. © 2020 International Parkinson and Movement Disorder Society.
原发性运动障碍患者对身体运动的时间结局的预测能力异常，并且这种能力可以通过小脑神经调节来改变。颈肌张力障碍的震颤可能与运动知觉任务的表现有关。
共纳入 15 名伴震颤和 14 名不伴震颤的颈肌张力障碍患者，以及 15 名年龄匹配的健康参与者，这些参与者在观看完显示不同运动（书写句子、球到达目标）的视频后，需要在不同的时间间隔对视频变暗部分进行终止估计。
在手部运动任务的所有时间间隔中，伴震颤的颈肌张力障碍患者的绝对时间误差均较大（组间×任务交互效应，F = 4.57；P = 0.016）。对于这两种运动任务，所有组的预期反应百分比没有差异，这表明没有时间误差的方向性。
颈肌张力障碍患者感知运动的时间处理与震颤的存在有关。颈肌张力障碍患者皮质-小脑网络异常可能导致这些患者的运动处理改变。
