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[阿根廷布宜诺斯艾利斯市一家儿科医院的非典型手足口病病毒基因分型]

[Atypical hand-foot-mouth disease virus genotyping in a pediatric hospital in Buenos Aires city, Argentina].

作者信息

Sapia Elizabeth Y, Maroni Camila, Groisman Carolina, Kromer Hilen, Lihue Rojo Gabriel, Dastugue Mónica, Valinotto Laura

机构信息

Hospital de Niños Dr. Ricardo Gutiérrez, Buenos Aires, Argentina.

Laboratorio de Virología, Hospital de Niños Dr. Ricardo Gutiérrez, Buenos Aires, Argentina.

出版信息

Arch Argent Pediatr. 2020 Apr;118(2):e199-e203. doi: 10.5546/aap.2020.e199.

Abstract

Typical hand-foot-mouth disease (HFMD) is an exanthematous viral disease with a classic symptomatology of fever, papulovesicular rash on the hands and feet with or without herpangina. It is usually caused by enterovirus 71 and Coxsackievirus A16, members of the genus Enterovirus. Recently, worldwide outbreaks of HFMD with atypical manifestations caused by Coxsackievirus A6 have been described. Atypical HFMD is considered an emerging disease due to its peculiar clinical and epidemiological characteristics: it affects adults, has a wide spectrum of clinical manifestations in the extension and distribution of the lesions and occurs in winter. The morphological characteristics of the lesions are very variable and can be misdiagnosed as chickenpox, impetigo or vasculitis. Here we describe the symptoms, clinical evolution, diagnostic methodology and treatment employed on a 4-yearold male patient with atypical HFMD.

摘要

典型手足口病(HFMD)是一种发疹性病毒性疾病,具有发热、手足部出现丘疹性水疱疹且伴有或不伴有疱疹性咽峡炎的典型症状。它通常由肠道病毒属的肠道病毒71型和柯萨奇病毒A16型引起。最近,已有关于由柯萨奇病毒A6引起的具有非典型表现的手足口病在全球范围内爆发的报道。非典型手足口病因其独特的临床和流行病学特征被视为一种新发疾病:它可累及成人,在皮损的范围和分布上有广泛的临床表现,且在冬季发病。皮损的形态特征变化很大,可能被误诊为水痘、脓疱病或血管炎。在此,我们描述一名患有非典型手足口病的4岁男性患者的症状、临床演变、诊断方法及治疗情况。

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