Clinical Laboratory, The First Hospital of Jilin University, Changchun, 130021, China.
Clinical Laboratory, The First Hospital of Jilin University, Changchun, 130021, China.
Colloids Surf B Biointerfaces. 2020 Jun;190:110966. doi: 10.1016/j.colsurfb.2020.110966. Epub 2020 Mar 12.
Despite the plethora of significant research progress made to develop novel strategies for the treatment of prostate cancer, this disease remains one of the major global health challenges among men. However, using a co-treatment approach utilizing two or more anticancer drugs has shown tremendous success in the treatment of many cancer types. Nanoliposomes are well known to encapsulate multiple drugs and deliver them at the desired site. In this work, we report the synthesis of nanoliposomes (∼100 nm) encapsulating two drugs, plumbagin, and genistein, to synergistically inhibit the growth of prostate cancer cells. The combination of plumbagin and genistein drugs was found inhibiting xenograft prostate tumor growth by ∼80 % without any appreciable toxicity. Mechanistically, the combination of plumbagin and genistein containing nanoliposomes leads to the inhibition of PI3K/AKT3 signaling pathway as well as the decreased population of Glut-1 transporters to impart the retardation in tumor growth. Decrease in proliferative cells and blood vessels are early biological processes that laid the foundation of the observed anti-tumor effect. Thus, a novel, and non-toxic liposomal formulation, containing plumbagin and genistein drugs, is reported, which can deliver anticancer agents to prostate tumors and inhibit the growth.
尽管在开发治疗前列腺癌的新策略方面取得了大量重要的研究进展，但这种疾病仍然是男性面临的主要全球健康挑战之一。然而，使用联合治疗方法，同时使用两种或更多种抗癌药物，已在治疗许多癌症类型方面取得了巨大成功。众所周知，纳米脂质体可以包裹多种药物并将其递送到所需的部位。在这项工作中，我们报告了合成纳米脂质体（约 100nm），将两种药物，即白花丹醌和染料木黄酮，包裹起来，以协同抑制前列腺癌细胞的生长。发现白花丹醌和染料木黄酮联合用药可抑制异种移植前列腺肿瘤生长约 80%，而无明显毒性。从机制上讲，包含白花丹醌和染料木黄酮的纳米脂质体的联合使用导致 PI3K/AKT3 信号通路的抑制以及 Glut-1 转运蛋白的数量减少，从而延缓肿瘤生长。增殖细胞和血管的减少是观察到的抗肿瘤作用的早期生物学过程。因此，报告了一种新型的、无毒的脂质体制剂，包含白花丹醌和染料木黄酮药物，可将抗癌药物递送到前列腺肿瘤并抑制其生长。
