营养不良相关性糖尿病患者自主神经及周围神经病变的高发生率。

High frequency of autonomic as well as peripheral neuropathy in patients with malnutrition-related diabetes mellitus.

作者信息

Sutjahjo A, Taniguchi H, Tjokroprawiro A, Baba S

机构信息

Department of Medicine, Airlangga University - Dr. Sutomo Hospital, Surabaya, Indonesia.

出版信息

Diabetes Res Clin Pract. 1988 Sep 5;5(3):197-200. doi: 10.1016/s0168-8227(88)80088-3.

DOI:10.1016/s0168-8227(88)80088-3

PMID:3219990

Abstract

We assessed peripheral and autonomic nerve function in 27 diabetics. Ten had malnutrition-related diabetes mellitus (MRDM), eight insulin-dependent diabetes mellitus (IDDM), and nine non-insulin-dependent diabetes mellitus (NIDDM). The frequency of peripheral neuropathy was 70, 78 and 13% in MRDM, NIDDM and IDDM respectively. Furthermore, the frequency of abnormality in cardiac beat-to-beat variation was 50 and 38% in MRDM and IDDM respectively, whereas our NIDDM patients did not show this abnormality. The patients with MRDM thus revealed a high frequency of not only peripheral but also autonomic neuropathy. Autonomic dysfunction appears to be a new characteristic of MRDM, not mentioned by the WHO study group.

摘要

我们评估了27名糖尿病患者的外周神经和自主神经功能。其中10例为营养不良相关性糖尿病（MRDM），8例为胰岛素依赖型糖尿病（IDDM），9例为非胰岛素依赖型糖尿病（NIDDM）。MRDM、NIDDM和IDDM患者外周神经病变的发生率分别为70%、78%和13%。此外，MRDM和IDDM患者逐搏心跳变异异常的发生率分别为50%和38%，而我们的NIDDM患者未出现这种异常。因此，MRDM患者不仅外周神经病变发生率高，自主神经病变发生率也高。自主神经功能障碍似乎是MRDM的一个新特征，世界卫生组织研究小组未提及。