Department of Medicine I, Medical University Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria.
Pulmonology. 2020 Sep-Oct;26(5):283-290. doi: 10.1016/j.pulmoe.2020.02.005. Epub 2020 Mar 18.
Lung cancer is a major global health problem. Several strategies are required to conquer this cancer. Stricter implementations of tobacco control measures are necessary. Early detection programs should be implemented to decrease lung cancer mortality. Although chemotherapy remains a cornerstone of treatment, targeted therapies and immune checkpoint inhibitors improved treatment of metastatic cancers and are hoped to improve outcome of adjuvant and induction therapies. Novel immunotherapy approaches hold great promise. Better understanding of the molecular biology of lung cancer should lead to rational drug design.
肺癌是一个全球性的主要健康问题。需要采取多种策略来攻克这一癌症。需要更严格地执行烟草控制措施。应实施早期检测计划,以降低肺癌死亡率。虽然化疗仍然是治疗的基石,但靶向治疗和免疫检查点抑制剂改善了转移性癌症的治疗效果,并有望改善辅助和诱导治疗的效果。新型免疫治疗方法前景广阔。更好地了解肺癌的分子生物学应该能够进行合理的药物设计。