Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA; Department of Dermatology, University of Maryland School of Medicine, Baltimore, Maryland, USA; Research and Development Service, VA Maryland Health Care System, Baltimore, Maryland, USA.
J Invest Dermatol. 2020 Apr;140(4):743-745. doi: 10.1016/j.jid.2019.11.025.
Wenzina et al. (2020) explore the potential role of E-cadherin (CDH1) as a marker for invasive behavior in melanoma. The authors show that CDH1 expression is modulated by p38 signaling, and that manipulation of this pathway can impede endothelial disruption and lung dissemination in vivo and in vitro. The downstream markers PODXL and DEL of the invasive phenotype are associated with a poor prognosis.
Wenzina 等人（2020 年）探讨了 E-钙黏蛋白（CDH1）作为黑色素瘤侵袭行为标志物的潜在作用。作者表明，CDH1 的表达受 p38 信号通路的调节，并且该途径的操作可以阻止体内和体外的内皮破坏和肺转移。侵袭表型的下游标志物 PODXL 和 DEL 与预后不良相关。
