School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, 721302, India.
School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, 721302, India.
Eur J Cell Biol. 2020 Apr;99(2-3):151073. doi: 10.1016/j.ejcb.2020.151073. Epub 2020 Mar 19.
Elevation of the level of intracellular reactive oxygen species (ROS) has immense implication in the biological system. On the one hand, ROS promote the signaling cascades for the maintenance of normal physiological functions, the phenomenon referred to as redox biology, and on the other hand increased ROS can cause damages to the cellular macromolecules as well as genetic material, the process known as oxidative stress. Oxidative stress acts as an etiological factor for wide varieties of pathologies, cancer being one of them. ROS is regarded as a "double-edged sword" with respect to oncogenesis. It can suppress as well as promote the malignant progression depending on the type of signaling pathway it uses. Moreover, the attribution of ROS in promoting phenotypic plasticity as well as acquisition of stemness during neoplasia has become a wide area of research. The current review discussed all the aspects of ROS in the perspective of tumor biology with special reference to epithelial-mesenchymal transition (EMT) and cancer stem cells.
细胞内活性氧（ROS）水平的升高对生物系统有巨大的影响。一方面，ROS 促进了维持正常生理功能的信号级联反应，这种现象被称为氧化还原生物学，另一方面，增加的 ROS 会对细胞大分子以及遗传物质造成损害，这个过程被称为氧化应激。氧化应激是多种病理学的病因之一，包括癌症。ROS 被认为是致癌过程中的一把“双刃剑”，它可以根据所使用的信号通路类型抑制或促进恶性进展。此外，ROS 在促进肿瘤发生过程中的表型可塑性和干性获得方面的作用已经成为一个广泛的研究领域。本综述从肿瘤生物学的角度讨论了 ROS 的各个方面，特别参考了上皮-间充质转化（EMT）和癌症干细胞。
