Department of Pharmacology, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, Karnataka, India.
Indian J Pharmacol. 2020 Jan-Feb;52(1):53-55. doi: 10.4103/ijp.IJP_169_18. Epub 2020 Mar 11.
During pregnancy, iron-deficiency anemia if untreated can affect the mother and child and hence iron is supplemented. Intolerance to oral iron therapy and malabsorption are common indications for parenteral iron therapy. The regularly used intravenous iron preparations are iron sucrose, sodium ferric gluconate, and iron dextran, of which iron sucrose has a satisfactory safety profile. We report a case of iron sucrose causing rare reaction with generalized edema in the mother, which was followed by intrauterine death. The oxidative stress due to immune-mediated mechanisms or adjuvant used in iron sucrose could cause mild rashes to severe anaphylactic reactions. This case report warns us toward the use of parenteral iron preparations in pregnant women, as one of the safe formulations could lead to an unusual fatal outcome in the fetus.
在妊娠期间,未经治疗的缺铁性贫血会影响母婴健康,因此需要补铁。口服铁剂不耐受和吸收不良是采用肠外铁剂治疗的常见指征。常用的静脉用铁剂包括蔗糖铁、葡萄糖酸亚铁钠和右旋糖酐铁,其中蔗糖铁具有良好的安全性。我们报告了 1 例蔗糖铁引起的罕见过敏反应,导致母亲全身水肿,随后宫内死亡。免疫介导机制或蔗糖铁中使用的佐剂引起的氧化应激可能导致轻度皮疹至严重过敏反应。本病例报告提醒我们在孕妇中使用肠外铁剂时要谨慎,因为即使是一种安全的制剂也可能导致胎儿出现异常的致命后果。