Waisman Y, Zahavi I, Marcus H, Ligumsky M, Rosenbach Y, Dinari G
Department of Pediatrics A, Beilinson Medical Center, Tel Aviv University Sackler School of Medicine, Petah Tiqva.
Digestion. 1988;41(2):78-82. doi: 10.1159/000199735.
The therapeutic effects of sucralfate on ulcerated gastric and duodenal mucosa is well known. There is, however, very little information about its effect on the mucosa of the small intestine. We studied the possible protective effect of sucralfate against indomethacin-induced intestinal ulceration in the rat. Sucralfate was found to possess a marked protective effect on the intestinal mucosa (ulcer index 23.16 +/- 6.58 vs. 225 +/- 36.37; p less than 0.001). Sucralfate elevated basal mucosal prostaglandin E2 generation (p less than 0.001), and partially overcame the inhibition of prostaglandin E2 synthesis caused by indomethacin (p less than 0.03), but had no effect on mucosal cAMP level. The effect of sucralfate on prostaglandin E2 content might partially explain its protective effect on the intestinal mucosa.
硫糖铝对胃和十二指肠溃疡黏膜的治疗作用是众所周知的。然而，关于其对小肠黏膜的作用的信息却非常少。我们研究了硫糖铝对吲哚美辛诱导的大鼠肠道溃疡的可能保护作用。发现硫糖铝对肠道黏膜具有显著的保护作用（溃疡指数23.16±6.58对比225±36.37；p<0.001）。硫糖铝提高了基础黏膜前列腺素E2的生成（p<0.001），并部分克服了吲哚美辛引起的前列腺素E2合成抑制（p<0.03），但对黏膜cAMP水平没有影响。硫糖铝对前列腺素E2含量的影响可能部分解释了其对肠道黏膜的保护作用。
