Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Hypertens Pregnancy. 2020 May;39(2):139-144. doi: 10.1080/10641955.2020.1745227. Epub 2020 Mar 22.
: To determine the predictive value of plasma soluble fms-like tyrosine kinase 1 (sFlt-1) and placental growth factor (PlGF) ratio for detection of preeclampsia in elderly gravida at 16-18 weeks of gestation and to identify whether abnormalities of this ratio are associated with any other pregnancy complications or not.: Blood samples of 300 cases were collected. Plasma sFlt-1 and PlGF levels were measured using an automated immunoassay.: Sensitivity and specificity for plasma sFlt-1/PlGF ratio above 9.8 for preeclampsia prediction were 85.7% and 61.2%, respectively. The sensitivity and specificity to predict early onset preeclampsia were 100% and 61.1%, respectively. Women with abnormal plasma sFlt-1/PlGF ratio were not associated with any other pregnancy complications.: sFlt-1/PlGF ratio at 16-18 weeks of gestation in elderly gravida has a high sensitivity for predicting preeclampsia, especially early onset preeclampsia.
确定妊娠 16-18 周高龄孕妇血浆可溶性 fms 样酪氨酸激酶 1（sFlt-1）和胎盘生长因子（PlGF）比值对预测子痫前期的预测价值，并确定该比值的异常是否与其他任何妊娠并发症有关。
收集了 300 例病例的血样。采用自动化免疫分析法测定血浆 sFlt-1 和 PlGF 水平。
血浆 sFlt-1/PlGF 比值大于 9.8 预测子痫前期的敏感性和特异性分别为 85.7%和 61.2%。预测早发型子痫前期的敏感性和特异性分别为 100%和 61.1%。血浆 sFlt-1/PlGF 比值异常的妇女与任何其他妊娠并发症无关。
妊娠 16-18 周高龄孕妇的 sFlt-1/PlGF 比值对预测子痫前期，尤其是早发型子痫前期具有较高的敏感性。
