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Hypercholesterolemia risk-associated GPR146 is an orphan G-protein coupled receptor that regulates blood cholesterol levels in humans and mice.与高胆固醇血症风险相关的GPR146是一种孤儿G蛋白偶联受体,可调节人和小鼠的血液胆固醇水平。
Cell Res. 2020 Apr;30(4):363-365. doi: 10.1038/s41422-020-0303-z. Epub 2020 Mar 20.
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GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis.GPR146 缺乏可预防高胆固醇血症和动脉粥样硬化。
Cell. 2019 Nov 27;179(6):1276-1288.e14. doi: 10.1016/j.cell.2019.10.034.
3
Orphan GPR146: an alternative therapeutic pathway to achieve cholesterol homeostasis?孤儿 GPR146:实现胆固醇平衡的另一种治疗途径?
Trends Endocrinol Metab. 2022 Jul;33(7):481-492. doi: 10.1016/j.tem.2022.04.008. Epub 2022 May 10.
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A gut-derived hormone regulates cholesterol metabolism.一种肠道来源的激素调节胆固醇代谢。
Cell. 2024 Mar 28;187(7):1685-1700.e18. doi: 10.1016/j.cell.2024.02.024. Epub 2024 Mar 18.
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GPR146: an emerging therapeutic target for hypercholesterolemia and atherosclerosis.GPR146:高胆固醇血症和动脉粥样硬化的新兴治疗靶点。
Acta Biochim Biophys Sin (Shanghai). 2020 Aug 5;52(8):914-915. doi: 10.1093/abbs/gmaa058.
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G protein-coupled receptor 146: new insights from genetics and model systems.G 蛋白偶联受体 146:遗传学和模型系统的新见解。
Curr Opin Lipidol. 2024 Jun 1;35(3):162-169. doi: 10.1097/MOL.0000000000000929. Epub 2024 Mar 8.
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Targeting orphan G protein-coupled receptors for the treatment of diabetes and its complications: C-peptide and GPR146.靶向孤儿G蛋白偶联受体治疗糖尿病及其并发症:C肽与GPR146
J Intern Med. 2017 Jan;281(1):25-40. doi: 10.1111/joim.12528. Epub 2016 Jun 16.
8
Evidence for an interaction between proinsulin C-peptide and GPR146.证据表明胰岛素原 C 肽与 GPR146 之间存在相互作用。
J Endocrinol. 2013 Jul 11;218(2):B1-8. doi: 10.1530/JOE-13-0203. Print 2013.
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Is GPR146 really the receptor for proinsulin C-peptide?GPR146 是否真的是胰岛素原 C 肽的受体?
Bioorg Med Chem Lett. 2020 Jul 1;30(13):127208. doi: 10.1016/j.bmcl.2020.127208. Epub 2020 Apr 20.
10
Evidence for an interaction between proinsulin C-peptide and GPR146.证据表明胰岛素原 C 肽与 GPR146 之间存在相互作用。
J Endocrinol. 2013;218(2):B1-8.

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Multi-ancestry sequencing-based genome-wide association study of C-reactive protein in 513,273 genomes.基于多祖先测序的513273个基因组中C反应蛋白的全基因组关联研究。
Nat Commun. 2025 Apr 24;16(1):3892. doi: 10.1038/s41467-025-59155-w.
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Systematic interrogation of functional genes underlying cholesterol and lipid homeostasis.对胆固醇和脂质稳态潜在功能基因的系统研究。
Genome Biol. 2025 Mar 17;26(1):59. doi: 10.1186/s13059-025-03531-8.
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Cholesin, a new hormone bridges intestinal cholesterol absorption and hepatic synthesis.胆素,一种连接肠道胆固醇吸收与肝脏合成的新激素。
Life Metab. 2024 Jun 7;3(4):loae024. doi: 10.1093/lifemeta/loae024. eCollection 2024 Aug.
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From Genetic Findings to new Intestinal Molecular Targets in Lipid Metabolism.从基因发现到脂质代谢中的新型肠道分子靶点
Curr Atheroscler Rep. 2025 Jan 11;27(1):26. doi: 10.1007/s11883-024-01264-w.
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Inhibition of liver cholesterol synthesis by a diet-induced gut hormone.饮食诱导的肠道激素对肝脏胆固醇合成的抑制作用。
Acta Pharm Sin B. 2024 Oct;14(10):4625-4627. doi: 10.1016/j.apsb.2024.07.026. Epub 2024 Aug 5.
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Postprandial exercise regulates tissue-specific triglyceride uptake through angiopoietin-like proteins.餐后运动通过血管生成素样蛋白调节组织特异性甘油三酯摄取。
JCI Insight. 2024 Aug 22;9(16):e181553. doi: 10.1172/jci.insight.181553.
7
Cholesin receptor signalling is active in cardiovascular system-associated adipose tissue and correlates with SGLT2i treatment in patients with diabetes.在与心血管系统相关的脂肪组织中,胆固醇受体信号活跃,并与糖尿病患者接受 SGLT2i 治疗相关。
Cardiovasc Diabetol. 2024 Jun 20;23(1):211. doi: 10.1186/s12933-024-02322-y.
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Identifying G protein-coupled receptors involved in adipose tissue function using the innovative RNA-seq database FATTLAS.利用创新型RNA测序数据库FATTLAS鉴定参与脂肪组织功能的G蛋白偶联受体。
iScience. 2023 Sep 9;26(10):107841. doi: 10.1016/j.isci.2023.107841. eCollection 2023 Oct 20.
9
Profiling of G-Protein Coupled Receptors in Adipose Tissue and Differentiating Adipocytes Offers a Translational Resource for Obesity/Metabolic Research.脂肪组织和分化脂肪细胞中的 G 蛋白偶联受体分析为肥胖/代谢研究提供了转化资源。
Cells. 2023 Jan 19;12(3):377. doi: 10.3390/cells12030377.
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The Progression of Treatment for Refractory Hypercholesterolemia: Focus on the Prospect of Gene Therapy.难治性高胆固醇血症的治疗进展:聚焦基因治疗前景
Front Genet. 2022 Jun 9;13:911429. doi: 10.3389/fgene.2022.911429. eCollection 2022.

Hypercholesterolemia risk-associated GPR146 is an orphan G-protein coupled receptor that regulates blood cholesterol levels in humans and mice.

作者信息

Han Fangfang, Liu Xiao, Chen Chuanfang, Liu Yinan, Du Mingkun, Zhou Yu, Liu Yong, Song Bao-Liang, He Housheng Hansen, Wang Yan

机构信息

Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, 430072, Wuhan, Hubei, China.

Princess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 1L7, Canada.

出版信息

Cell Res. 2020 Apr;30(4):363-365. doi: 10.1038/s41422-020-0303-z. Epub 2020 Mar 20.

DOI:10.1038/s41422-020-0303-z
PMID:32203133
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7118070/
Abstract
摘要