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Is it beneficial to use hydroxychloroquine and imatinib combination in order to achieve deeper molecular responses in patients with chronic myeloid leukemia?

作者信息

Eşkazan Ahmet Emre

机构信息

Division of Hematology, Department of Internal Medicine, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.

出版信息

Leukemia. 2020 Dec;34(12):3426-3427. doi: 10.1038/s41375-020-0796-y. Epub 2020 Mar 13.

DOI:10.1038/s41375-020-0796-y
PMID:32203136
Abstract
摘要

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Is it beneficial to use hydroxychloroquine and imatinib combination in order to achieve deeper molecular responses in patients with chronic myeloid leukemia?为使慢性髓性白血病患者获得更深的分子反应，联合使用羟氯喹和伊马替尼是否有益？
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Dasatinib rapidly induces deep molecular response in chronic-phase chronic myeloid leukemia patients who achieved major molecular response with detectable levels of BCR-ABL1 transcripts by imatinib therapy.达沙替尼可快速诱导伊马替尼治疗后 BCR-ABL1 转录本可检测到的慢性期慢性髓性白血病患者获得主要分子学反应的深层分子反应。
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Concordant optimal molecular and cytogenetic responses at both 3 and 6 months predict a higher probability of MR4.5 achievement in patients with chronic myeloid leukemia treated with imatinib.在接受伊马替尼治疗的慢性髓性白血病患者中，3个月和6个月时一致的最佳分子和细胞遗传学反应预示着达到MR4.5的可能性更高。
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Plasma imatinib trough level measurements is still appropriate to predict therapeutic responses in patients with chronic myeloid leukemia.检测慢性髓性白血病患者的血浆伊马替尼谷浓度，对于预测其治疗反应仍具有重要意义。
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The predictive value of early molecular response in chronic myeloid leukaemia patients treated with imatinib in a single real-world medical centre in a developing country.在一个发展中国家的单一真实世界医疗中心接受伊马替尼治疗的慢性髓性白血病患者中，早期分子反应的预测价值。
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