Center for Bioengineering and Nanomedicine, Department of Food Science, University of Otago, Dunedin, New Zealand.
Center for Bioengineering and Nanomedicine, Department of Food Science, University of Otago, Dunedin, New Zealand.
Mater Sci Eng C Mater Biol Appl. 2020 May;110:110612. doi: 10.1016/j.msec.2019.110612. Epub 2020 Jan 7.
Keratins are a family of fibrous proteins anticipated to possess wide-ranging biomedical applications due to their abundance, physicochemical properties and intrinsic biological activity. This review mainly focuses on the biomaterials derived from three major sources of keratins; namely human hair, wool and feather, that have effective applications in tissue engineering, wound healing and drug delivery. This article offers five viewpoints regarding keratin i) an introduction to keratin protein extraction and keratin-based scaffold fabrication methods ii) applications in nerve and bone tissue engineering iii) a review on the keratin dressings applied to different types of wounds to facilitate wound healing and thereby repair the skin iv) the utilization of keratinous materials as a carrier system for therapeutics with a controlled manner v) a discussion regarding the main challenges for using keratin in biomedical applications as well as its future prospects.
角蛋白是一类纤维状蛋白质，由于其丰富的含量、物理化学性质和内在的生物活性，预计具有广泛的生物医学应用。本文主要集中于三种主要角蛋白来源的生物材料；即人发、羊毛和羽毛，这些材料在组织工程、伤口愈合和药物输送方面具有有效的应用。本文从五个方面对角蛋白进行了讨论：i）角蛋白蛋白提取和基于角蛋白支架制备方法的介绍；ii）在神经和骨组织工程中的应用；iii）用于不同类型伤口的角蛋白敷料的综述，以促进伤口愈合，从而修复皮肤；iv）角蛋白材料作为治疗载体系统的利用，以控制的方式；v）讨论角蛋白在生物医学应用中的主要挑战及其未来前景。
