Allen D C, Connolly N S, Biggart J D
Histopathology Laboratory, Belfast City Hospital, Northern Ireland.
Histopathology. 1988 Oct;13(4):399-411. doi: 10.1111/j.1365-2559.1988.tb02056.x.
The presence of mucosal hyperplasia and sialomucin goblet cell secretion (transitional mucosa) was assessed in various benign, premalignant and malignant colorectal tissues. Transitional mucosa was seen in diverticular disease, solitary ulcer syndrome of the rectum, ischaemic and irradiation colitis and other diseases including pneumatosis coli, endometriosis, haemorrhoids and a colostomy margin. Adenocarcinomas had a sulphomucin or mixed secretion pattern with transitional features in the adjacent mucosa mucosa (18/27). Premalignant adenomatous polyps showed mixed secretion with transitional glands incorporated in the stalk and sometimes in the adjacent mucosa. Epithelium showing dysplasia secreted sulphomucins and in amounts related to its degree of differentiation. Transitional mucosa may not be a primary premalignant phenomemon. The conclusion and unifying concept is that it is a secondary event related to goblet cell immaturity. This can occur, secondary to proliferation in mucosal inflammation, ischaemia and prolapse or as a phenotypic expression of growth derived from underlying dysplastic epithelium.
在各种良性、癌前和恶性结直肠组织中评估了黏膜增生和唾液黏蛋白杯状细胞分泌（移行黏膜）的情况。在憩室病、直肠孤立性溃疡综合征、缺血性和放射性结肠炎以及其他疾病（包括结肠积气、子宫内膜异位症、痔疮和结肠造口边缘）中可见移行黏膜。腺癌具有硫黏蛋白或混合分泌模式，相邻黏膜有移行特征（18/27）。癌前腺瘤性息肉表现为混合分泌，移行腺体存在于蒂部，有时也存在于相邻黏膜中。显示发育异常的上皮分泌硫黏蛋白，其分泌量与其分化程度相关。移行黏膜可能不是原发性癌前现象。结论和统一概念是，它是与杯状细胞不成熟相关的继发性事件。这可能继发于黏膜炎症、缺血和脱垂中的增殖，或者是源自潜在发育异常上皮的生长的表型表达。
