循环肿瘤 DNA 生物标志物在寡转移早期检测中的应用。
Circulating Tumor DNA Biomarkers for Early Detection of Oligometastasis.
机构信息
From the Department of Radiation Oncology, Mayo Clinic, Rochester, MN.
Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC.
出版信息
Cancer J. 2020 Mar/Apr;26(2):116-123. doi: 10.1097/PPO.0000000000000437.
Abstract
Oligometastasis represents an intermediate disease stage between localized and widely metastatic cancer. Efficient identification of patients with oligometastasis remains a barrier for accrual on clinical trials of oligometastasis-directed therapy. Here we review the prospect of circulating tumor DNA-based monitoring to promote sensitive, specific, and cost-efficient detection of cancer recurrence during posttreatment surveillance. Thus, an impetus for the development and implementation of clinical-grade circulating tumor DNA assays should be for the positive impact they will have on clinical investigations of oligometastasis-directed therapy.
摘要
寡转移代表了局限性癌症和广泛转移癌症之间的中间疾病阶段。有效地识别寡转移患者仍然是寡转移定向治疗临床试验入组的障碍。在这里，我们回顾了基于循环肿瘤 DNA 的监测在促进治疗后监测期间癌症复发的敏感、特异和具有成本效益的检测方面的前景。因此，开发和实施临床级别的循环肿瘤 DNA 检测的动力应该是它们对寡转移定向治疗的临床研究产生的积极影响。
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