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Value of venous thromboembolism prophylaxis by enoxaparin with anti-factor Xa trough concentration monitoring in surgical care.在外科护理中通过依诺肝素进行静脉血栓栓塞预防并监测抗Xa因子谷浓度的价值。
Pharm Pract (Granada). 2020 Jan-Mar;18(1):1808. doi: 10.18549/PharmPract.2020.1.1808. Epub 2020 Feb 17.
2
Trauma patients with lower extremity and pelvic fractures: Should anti-factor Xa trough level guide prophylactic enoxaparin dose?创伤下肢和骨盆骨折患者：抗因子 Xa 浓度谷底值是否应指导预防性依诺肝素剂量？
Int J Surg. 2018 Mar;51:128-132. doi: 10.1016/j.ijsu.2018.01.023. Epub 2018 Jan 31.
3
Utility of anti-factor Xa monitoring in surgical patients receiving prophylactic doses of enoxaparin for venous thromboembolism prophylaxis.抗Xa因子监测在接受预防剂量依诺肝素预防静脉血栓栓塞的外科患者中的效用。
Am J Surg. 2017 Jun;213(6):1143-1152. doi: 10.1016/j.amjsurg.2016.08.010. Epub 2016 Sep 2.
4
Association Between Enoxaparin Dosage Adjusted by Anti-Factor Xa Trough Level and Clinically Evident Venous Thromboembolism After Trauma.依抗 Xa 因子低谷水平调整的依诺肝素剂量与创伤后临床明显静脉血栓栓塞的相关性。
JAMA Surg. 2016 Nov 1;151(11):1006-1013. doi: 10.1001/jamasurg.2016.1662.
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Body weight does not predict for anti-Xa levels after fixed dose prophylaxis with enoxaparin after orthopedic surgery.骨科手术后使用固定剂量依诺肝素进行预防时，体重不能预测抗Xa因子水平。
Thromb Res. 1998 Aug 1;91(3):137-42. doi: 10.1016/s0049-3848(98)00083-8.
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Fixed or Weight-Tiered Enoxaparin After Thoracic Surgery for Venous Thromboembolism Prevention.胸部手术后固定剂量或体重分级依诺肝素预防静脉血栓栓塞症。
Ann Thorac Surg. 2020 Jun;109(6):1713-1721. doi: 10.1016/j.athoracsur.2019.12.058. Epub 2020 Feb 8.
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Standard prophylactic enoxaparin dosing leads to inadequate anti-Xa levels and increased deep venous thrombosis rates in critically ill trauma and surgical patients.标准预防性依诺肝素给药方案会导致重症创伤和外科手术患者的抗Xa水平不足，深静脉血栓形成率增加。
J Trauma. 2010 Apr;68(4):874-80. doi: 10.1097/TA.0b013e3181d32271.
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Antifactor Xa levels in four patients with burn injuries who received enoxaparin to prevent venous thromboembolism.四名接受依诺肝素预防静脉血栓栓塞的烧伤患者的抗Xa因子水平。
Pharmacotherapy. 2004 Dec;24(12):1793-9. doi: 10.1592/phco.24.17.1793.52344.
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Prospective Evaluation of Weight-Based Prophylactic Enoxaparin Dosing in Critically Ill Trauma Patients: Adequacy of AntiXa Levels Is Improved.重症创伤患者基于体重的预防性依诺肝素剂量的前瞻性评估：抗Xa水平的充足性得到改善。
Am Surg. 2015 Jun;81(6):605-9.
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Anti-Xa-guided enoxaparin thromboprophylaxis reduces rate of deep venous thromboembolism in high-risk trauma patients.抗Xa因子指导下的依诺肝素血栓预防可降低高危创伤患者深静脉血栓形成的发生率。
J Trauma Acute Care Surg. 2016 Dec;81(6):1101-1108. doi: 10.1097/TA.0000000000001193.

本文引用的文献

1
Pharmacist recommendations for prophylactic enoxaparin monitoring and dose adjustment in trauma patients admitted to a surgical intensive care unit.药师对入住外科重症监护病房的创伤患者预防性使用依诺肝素监测及剂量调整的建议。
Pharm Pract (Granada). 2019 Oct-Dec;17(4):1541. doi: 10.18549/PharmPract.2019.4.1541. Epub 2019 Oct 31.
2
The impact of pharmacological thromboprophylaxis and disease-stage on postoperative bleeding following colorectal cancer surgery.药物性血栓预防和疾病分期对结直肠癌手术后出血的影响。
World J Surg Oncol. 2019 Jun 27;17(1):110. doi: 10.1186/s12957-019-1653-1.
3
Factor Xa Inhibitors and Direct Thrombin Inhibitors Versus Low-Molecular-Weight Heparin for Thromboprophylaxis After Total Hip or Total Knee Arthroplasty: A Systematic Review and Meta-Analysis.Xa 因子抑制剂和直接凝血酶抑制剂与低分子肝素在全髋关节或全膝关节置换术后预防血栓形成的比较：系统评价和荟萃分析。
J Arthroplasty. 2019 Apr;34(4):789-800.e6. doi: 10.1016/j.arth.2018.11.029. Epub 2018 Dec 1.
4
Anti-Xa-guided enoxaparin thromboprophylaxis reduces rate of deep venous thromboembolism in high-risk trauma patients.抗Xa因子指导下的依诺肝素血栓预防可降低高危创伤患者深静脉血栓形成的发生率。
J Trauma Acute Care Surg. 2016 Dec;81(6):1101-1108. doi: 10.1097/TA.0000000000001193.
5
Association Between Enoxaparin Dosage Adjusted by Anti-Factor Xa Trough Level and Clinically Evident Venous Thromboembolism After Trauma.依抗 Xa 因子低谷水平调整的依诺肝素剂量与创伤后临床明显静脉血栓栓塞的相关性。
JAMA Surg. 2016 Nov 1;151(11):1006-1013. doi: 10.1001/jamasurg.2016.1662.

Value of venous thromboembolism prophylaxis by enoxaparin with anti-factor Xa trough concentration monitoring in surgical care.

作者信息

Zachariah Seeba, Al-Tamimi Maitha, Vippadapu Prasanna, Shenouda Wessa, Thomas Dixon

机构信息

PhD, MPharm. Clinical Lecturer. Department of Pharmacy Practice, College of Pharmacy, Gulf Medical University. Ajman (United Arab Emirates).

BPharm. Department of Pharmacy Practice, College of Pharmacy, Gulf Medical University. Ajman (United Arab Emirates).

出版信息

Pharm Pract (Granada). 2020 Jan-Mar;18(1):1808. doi: 10.18549/PharmPract.2020.1.1808. Epub 2020 Feb 17.

DOI:10.18549/PharmPract.2020.1.1808
PMID:32206143
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7075425/
Abstract
摘要