Dias Natália S, Barbosa Izabela G, Kuang Weihong, Teixeira Antonio L
Neuroscience Program, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Department of Mental Health, School of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Dement Neuropsychol. 2020 Jan-Mar;14(1):1-6. doi: 10.1590/1980-57642020dn14-010001.
The relationship between depressive disorders in the elderly and dementia, particularly Alzheimer's disease (AD), is highly complex. While the nature of this relationship is still a matter of debate, differential diagnosis and treatment remain a great clinical challenge. We review recent findings on the conundrum of depressive disorders in the elderly and AD. There is a biological continuum between depressive disorders in the elderly - or at least a subgroup of them - and AD. While elderly subjects with depression and patients with AD exhibit higher circulating levels of pro-inflammatory molecules and lower BDNF than matched controls, CSF levels of Aβ42 can discriminate AD from depressive disorders in the elderly. The role of antidepressant treatment as a strategy to minimize the risk of AD remains to be established.
老年人抑郁症与痴呆症，尤其是阿尔茨海默病（AD）之间的关系极为复杂。尽管这种关系的本质仍存在争议，但鉴别诊断和治疗仍是一项重大的临床挑战。我们回顾了关于老年人抑郁症与AD难题的最新研究结果。老年人抑郁症——或者至少其中一个亚组——与AD之间存在生物学上的连续性。虽然患有抑郁症的老年受试者和AD患者比匹配的对照组表现出更高水平的促炎分子循环和更低的脑源性神经营养因子（BDNF），但脑脊液中β淀粉样蛋白42（Aβ42）水平可以区分老年人的AD和抑郁症。抗抑郁治疗作为一种降低AD风险策略的作用仍有待确定。
