Barbara Davis Center, University of Colorado Denver Anschutz Medical Campus, Aurora, CO 80045, USA.
Barbara Davis Center, University of Colorado Denver Anschutz Medical Campus, Aurora, CO 80045, USA.
Dev Cell. 2020 Mar 23;52(6):681-682. doi: 10.1016/j.devcel.2020.02.018.
Notch signaling is a major regulator of pancreas development, yet how it precisely controls pancreatic cell fates has remained obscure. Seymour et al. (2020) use sophisticated Notch- based genetic tools to uncover highly context- and temporally-specific roles for DLL1, JAG1, and HES1 in regulating pancreatic progenitor cell growth and specification.
Notch 信号通路是胰腺发育的主要调节因子，但它如何精确控制胰腺细胞命运仍不清楚。Seymour 等人（2020 年）利用复杂的 Notch 遗传工具，揭示了 DLL1、JAG1 和 HES1 在调节胰腺祖细胞生长和分化方面具有高度的上下文和时间特异性作用。
