Nylund Marjo, Vuorinen Tytti, Airas Laura
Division of Clinical Neurosciences, Turku University Hospital and University of Turku, Turku, Finland.
Department of Clinical Microbiology, Turku University Hospital and Institute of Biomedicine, University of Turku, Turku, Finland.
Mult Scler Relat Disord. 2020 Jul;42:102058. doi: 10.1016/j.msard.2020.102058. Epub 2020 Mar 14.
We report here on a young woman with multiple sclerosis, who developed a condition with eosinophilia and swelling of limbs seven weeks after initiation of ocrelizumab treatment. We consider her drug reaction to be compatible with a drug reaction with eosinophilia and systemic symptoms (DRESS), also called drug-induced hypersensitivity syndrome. She was treated with antihistamine and corticosteroid treatments, and recovered fully within three months of symptom onset. Ocrelizumab was not re-initiated. We are not aware of other DRESS-like cases related to ocrelizumab treatment.
我们在此报告一名患有多发性硬化症的年轻女性，她在开始使用奥瑞珠单抗治疗七周后出现了嗜酸性粒细胞增多和肢体肿胀的情况。我们认为她的药物反应符合伴有嗜酸性粒细胞增多和全身症状的药物反应（DRESS），也称为药物性超敏反应综合征。她接受了抗组胺药和皮质类固醇治疗，并在症状出现后的三个月内完全康复。未重新启用奥瑞珠单抗。我们未发现其他与奥瑞珠单抗治疗相关的类DRESS病例。
