School of Public Health, Nanjing Medical University , Nanjing, PR China.
Vaccine Clinical Evaluation Department, Jiangsu Provincial Center for Disease Control and Prevention , Nanjing, PR China.
Hum Vaccin Immunother. 2020 Jul 2;16(7):1579-1585. doi: 10.1080/21645515.2020.1737465. Epub 2020 Mar 25.
Enterovirus 71 (EV71) is the dominant pathogen in severe and fatal hand-foot-mouth disease (HFMD) cases. Since 2015, three inactivated EV71 vaccines have been approved in China. The vaccination coverage of the EV71 vaccine has been relatively low, especially in rural areas. A cross-sectional survey from July 19 to August 22, 2018, was conducted in three rural counties of northern Jiangsu Province among parents of children aged 6-60 months. We adopted a pretested validated questionnaire to assess knowledge, awareness, and attitude of HFMD and EV71 vaccines among respondents and used univariate and multivariate binary logistic analyses to explore potential factors associated with the acceptance of EV71 vaccines. Of the 1,112 parents who participated, 87.8% were willing to vaccinate their children with EV71 vaccines. Parents over 40 y old were less likely to have their children vaccinated [adjusted odds ratio (aOR) = 2.12, 95% confidence interval (CI): 1.13-3.97]. Parents who lived in Ganyu (aOR = 0.50, 95% CI: 0.31-0.79) or Xinyi county (aOR = 0.33, 95% CI: 0.20-0.53), had a university or higher degree (aOR = 0.26, 95% CI: 0.11-0.64), had good knowledge of EV71 vaccines (aOR = 0.81, 95% CI: 0.67-0.98), perceived their children's disease susceptibility, and worried about the severity of HFMD had a higher willingness to vaccinate their children. Most parents were willing to vaccinate their children against EV71-related HFMD. Parental age, location, education level, knowledge of EV71 vaccines, concern about susceptibility, and severity of HFMD were all factors that influenced willingness to vaccinate.
肠道病毒 71 型（EV71）是引起重症和致死性手足口病（HFMD）的主要病原体。自 2015 年以来，中国已批准三种肠道病毒 71 型灭活疫苗。EV71 疫苗的接种率相对较低，特别是在农村地区。2018 年 7 月 19 日至 8 月 22 日，我们在江苏省北部的三个农村县对 6-60 月龄儿童的家长进行了横断面调查。我们采用预先测试的有效问卷评估了受访者对手足口病和 EV71 疫苗的知识、意识和态度，并采用单变量和多变量二元逻辑分析探讨了与接受 EV71 疫苗相关的潜在因素。在 1112 名参与的父母中，87.8%的父母愿意为孩子接种 EV71 疫苗。40 岁以上的父母不太可能为孩子接种疫苗[调整后的优势比（aOR）=2.12，95%置信区间（CI）：1.13-3.97]。居住在赣榆（aOR=0.50，95%CI：0.31-0.79）或新沂县（aOR=0.33，95%CI：0.20-0.53）的父母、具有大学或以上学历（aOR=0.26，95%CI：0.11-0.64）、对 EV71 疫苗有较好的了解（aOR=0.81，95%CI：0.67-0.98）、认为自己孩子易患该病且担心 HFMD 严重程度的父母，更愿意为孩子接种疫苗。大多数父母愿意为孩子接种预防 EV71 相关 HFMD 的疫苗。父母的年龄、地点、教育程度、对 EV71 疫苗的了解、对易感性的关注以及对手足口病严重程度的担忧都是影响接种意愿的因素。
