Nucleus of Research in Therapeutical Innovation Suely Galdino (NUPIT SG), Bioscience Center, Federal University of Pernambuco, Recife, Brazil.
Curr Org Synth. 2020;17(4):252-270. doi: 10.2174/1570179417666200325124712.
Phthalimide derivatives have been presenting several promising biological activities in the literature, such as anti-inflammatory, analgesic, antitumor, antimicrobial and anticonvulsant. The most well-known and studied phthalimide derivative (isoindoline-1,3-dione) is thalidomide: this compound initially presented important sedative effects, but it is now known that thalidomide has effectiveness against a wide variety of diseases, including inflammation and cancer. This review approaches some of the recent and efficient chemical synthesis pathways to obtain phthalimide analogues and also presents a summary of the main biological activities of these derivatives found in the literature. Therefore, this review describes the chemical and therapeutic aspects of phthalimide derivatives.
邻苯二甲酰亚胺衍生物在文献中表现出多种有前途的生物活性，如抗炎、镇痛、抗肿瘤、抗菌和抗惊厥。最著名和研究最多的邻苯二甲酰亚胺衍生物（异吲哚啉-1,3-二酮）是沙利度胺：这种化合物最初具有重要的镇静作用，但现在已知沙利度胺对多种疾病有效，包括炎症和癌症。本文综述了一些获得邻苯二甲酰亚胺类似物的最新和有效的化学合成途径，并对文献中发现的这些衍生物的主要生物活性进行了总结。因此，本文描述了邻苯二甲酰亚胺衍生物的化学和治疗方面。
