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编辑精选 - 基于对两个中心队列的回顾性评估,检测血管内腹主动脉瘤修复后的晚期并发症及其对随访的影响。

Editor's Choice - Detection of Late Complications After Endovascular Abdominal Aortic Aneurysm Repair and Implications for Follow up Based on Retrospective Assessment of a Two Centre Cohort.

机构信息

Department of Surgical Sciences, Vascular Surgery, Uppsala University, Uppsala, Sweden.

Department of Surgical Sciences, Vascular Surgery, Uppsala University, Uppsala, Sweden.

出版信息

Eur J Vasc Endovasc Surg. 2020 Aug;60(2):171-179. doi: 10.1016/j.ejvs.2020.02.021. Epub 2020 Mar 21.

Abstract

OBJECTIVE

Endovascular aortic aneurysm repair (EVAR) is associated with the risk of late complications and mandates follow up. This retrospective study assessed post-EVAR complications in a two centre cohort. The study evaluated the rate of complications presenting with symptoms vs. those detected by imaging follow up. Additionally, the agreement between DUS and CTA in detecting complications was assessed in patients with both.

METHODS

All EVAR patients from 1998 to 2012 in two centres were included. Complications were classified based on whether they were symptomatic or detected by imaging, as well as based on imaging detection modality (DUS or CTA). For patients who had undergone DUS and CTA within three months of each other, the kappa coefficient of agreement was assessed.

RESULTS

Four hundred and fifty-four patients treated by EVAR were identified. The median follow up time was 5.2 (IQR 2.8-7.6) years. One hundred and eighteen patients (26%) developed 176 complications. One hundred and six (60.2%) of the complications were asymptomatic, and 70 (39.8%) were symptomatic. Two hundred and fifty-three patients had imaging with both modalities within three months of each other; the kappa coefficient for agreement between CTA and DUS for detecting clinically significant complications was 0.91. Regarding CTA as the standard modality, DUS had a sensitivity of 88.8% (95% CI 77.3-95.8%) and a specificity of 99.4% (95% CI 97.1-99.9%). Three of the complications missed by DUS were related to loss of proximal and distal seal, all occurring in patients with short sealing length on first post-operative CT scan.

CONCLUSION

Approximately a quarter of the patients developed complications, the majority of which were asymptomatic, underlining the importance of adequate surveillance. There was good agreement between CTA and DUS in detecting complications. Clinically significant complications related to inadequate seal were missed by DUS, suggesting that CTA still plays an important role in EVAR surveillance.

摘要

目的

血管内主动脉瘤修复术(EVAR)与晚期并发症的风险相关,需要进行随访。本回顾性研究评估了两个中心队列中 EVAR 后的并发症。该研究评估了以症状表现和影像学随访检测到的并发症发生率。此外,还评估了在同时进行 DUS 和 CTA 的患者中,两种方法检测并发症的一致性。

方法

纳入了 1998 年至 2012 年在两个中心接受 EVAR 的所有患者。根据并发症是否有症状或通过影像学检测到,以及根据影像学检测方法(DUS 或 CTA)对其进行分类。对于在三个月内同时进行 DUS 和 CTA 的患者,评估了kappa 系数一致性。

结果

共确定了 454 例接受 EVAR 治疗的患者。中位随访时间为 5.2(IQR 2.8-7.6)年。118 例患者(26%)发生了 176 种并发症。106 例(60.2%)并发症无症状,70 例(39.8%)有症状。253 例患者在三个月内同时进行了两种影像学检查;CTA 和 DUS 检测有临床意义的并发症的kappa 系数一致性为 0.91。以 CTA 为标准,DUS 的敏感度为 88.8%(95%CI 77.3-95.8%),特异度为 99.4%(95%CI 97.1-99.9%)。DUS 漏诊的 3 种并发症与近端和远端密封失效有关,均发生在术后首次 CT 扫描时密封长度较短的患者中。

结论

大约四分之一的患者发生了并发症,其中大多数为无症状,这突出了充分监测的重要性。CTA 和 DUS 在检测并发症方面具有良好的一致性。DUS 漏诊了与密封不充分相关的有临床意义的并发症,提示 CTA 在 EVAR 监测中仍发挥着重要作用。

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