North West Cancer Research Institute, School of Medical Sciences, Bangor University, Deiniol Road, Bangor, Gwynedd LL57 2UW, UK.
North West Cancer Research Institute, School of Medical Sciences, Bangor University, Deiniol Road, Bangor, Gwynedd LL57 2UW, UK.
Trends Cancer. 2020 Apr;6(4):271-273. doi: 10.1016/j.trecan.2020.01.014. Epub 2020 Feb 19.
New approaches to drug discovery are unlocking enormous therapeutic potential residing in cancer-specific molecules. Brachyury is emerging as an exciting new drug target for the rare bone cancer chordoma. Here, recent advances targeting Brachyury in chordoma are discussed and how these might open doors to the targeting of other, more common cancer types.
新的药物发现方法正在挖掘潜藏在癌症特异性分子中的巨大治疗潜力。Brachyury 正在成为一种针对罕见骨癌 chordoma 的令人兴奋的新药物靶点。本文讨论了目前针对 chordoma 中 Brachyury 的最新进展，以及这些进展如何为针对其他更常见癌症类型的靶向治疗打开大门。
