Center for Brain Immunology and Glia (BIG), University of Virginia, Charlottesville, VA 22908, USA; Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA.
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA; Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA.
Trends Neurosci. 2020 Apr;43(4):197-199. doi: 10.1016/j.tins.2020.01.008. Epub 2020 Feb 15.
In vivo two-photon imaging of microglia in the intact brain has revealed that microglia constantly survey neuronal soma. Research over the past decade and a recent paper by Cserép et al. published in Science are now uncovering the nature, mechanisms, and consequences of these interactions in health and injury.
在完整大脑中的活体双光子成像揭示了小胶质细胞持续监测神经元胞体。过去十年的研究和最近 Cserép 等人在《科学》杂志上发表的一篇论文,正在揭示这些在健康和损伤状态下的相互作用的性质、机制和后果。