抗利尿激素分泌异常综合征与嗜酸性肉芽肿性多血管炎相关。
Syndrome of inappropriate antidiuretic hormone associated with eosinophilic granulomatosis and polyangiitis.
作者信息
Lundin Michael S, Kaw Beenu, Pahwa Rajit
机构信息
Internal Medicine, Michigan State University, East Lansing, Michigan, USA
Internal Medicine, Sparrow Hospital, Lansing, Michigan, USA.
出版信息
BMJ Case Rep. 2020 Mar 24;13(3):e231249. doi: 10.1136/bcr-2019-231249.
A 62-year-old man presented with classic signs and symptoms of eosinophilic granulomatosis and polyangiitis (EGPA, also known as Churg-Strauss syndrome)-mononeuritis multiplex, palpable purpura, hypereosinophilia, positive P-ANCA (perinuclear anti-neutrophil cytoplasmic antibodies) developed diffuse alveolar haemorrhage. The patient had longstanding mild hyponatraemia, but developed moderate and symptomatic hyponatraemia characteristic of the syndrome of inappropriate antidiuretic hormone. The patient's serum sodium returned to his baseline- mildly hyponatraemic, after initiation of treatment targeted towards EGPA.
一名62岁男性出现嗜酸性肉芽肿性多血管炎（EGPA，又称Churg-Strauss综合征）的典型症状和体征——多发性单神经炎、可触及的紫癜、嗜酸性粒细胞增多、核周型抗中性粒细胞胞浆抗体（P-ANCA）阳性，随后发生弥漫性肺泡出血。该患者长期存在轻度低钠血症，但后来出现了抗利尿激素分泌不当综合征的中度且有症状的低钠血症。在针对EGPA开始治疗后，患者的血清钠恢复到基线水平——轻度低钠血症。
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