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本文引用的文献

1
Syndrome of Inappropriate Antidiuretic Hormone Associated with Eosinophilic Granulomatosis with Polyangiitis.抗利尿激素分泌异常综合征合并嗜酸性肉芽肿性多血管炎
Intern Med. 2016;55(9):1199-202. doi: 10.2169/internalmedicine.55.5122. Epub 2016 May 1.
2
Urea for treatment of acute SIADH in patients with subarachnoid hemorrhage: a single-center experience.尿素治疗蛛网膜下腔出血患者急性抗利尿激素分泌不当综合征：单中心经验。
Ann Intensive Care. 2012 May 30;2(1):13. doi: 10.1186/2110-5820-2-13.
3
Efficacy and tolerance of urea compared with vaptans for long-term treatment of patients with SIADH.与 vaptans 相比，尿素治疗 SIADH 患者的长期疗效和耐受性。
Clin J Am Soc Nephrol. 2012 May;7(5):742-7. doi: 10.2215/CJN.06990711. Epub 2012 Mar 8.
4
Clinical practice. The syndrome of inappropriate antidiuresis.临床实践。抗利尿激素分泌失调综合征
N Engl J Med. 2007 May 17;356(20):2064-72. doi: 10.1056/NEJMcp066837.
5
[Severe peripheral neuropathy, cardiac hypofunction, and syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in a patient with Churg-Strauss syndrome].[一名患有变应性肉芽肿性血管炎综合征的患者出现严重周围神经病变、心脏功能减退及抗利尿激素分泌异常综合征（SIADH）]
Ryumachi. 1999 Oct;39(5):774-7.
6
Treatment of the syndrome of inappropriate secretion of antidiuretic hormone by urea.用尿素治疗抗利尿激素分泌不当综合征。
Am J Med. 1980 Jul;69(1):99-106. doi: 10.1016/0002-9343(80)90506-9.

抗利尿激素分泌异常综合征与嗜酸性肉芽肿性多血管炎相关。

Syndrome of inappropriate antidiuretic hormone associated with eosinophilic granulomatosis and polyangiitis.

作者信息

Lundin Michael S, Kaw Beenu, Pahwa Rajit

机构信息

Internal Medicine, Michigan State University, East Lansing, Michigan, USA

Internal Medicine, Sparrow Hospital, Lansing, Michigan, USA.

出版信息

BMJ Case Rep. 2020 Mar 24;13(3):e231249. doi: 10.1136/bcr-2019-231249.

DOI:10.1136/bcr-2019-231249
PMID:32209573
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7103785/
Abstract

A 62-year-old man presented with classic signs and symptoms of eosinophilic granulomatosis and polyangiitis (EGPA, also known as Churg-Strauss syndrome)-mononeuritis multiplex, palpable purpura, hypereosinophilia, positive P-ANCA (perinuclear anti-neutrophil cytoplasmic antibodies) developed diffuse alveolar haemorrhage. The patient had longstanding mild hyponatraemia, but developed moderate and symptomatic hyponatraemia characteristic of the syndrome of inappropriate antidiuretic hormone. The patient's serum sodium returned to his baseline- mildly hyponatraemic, after initiation of treatment targeted towards EGPA.

摘要

一名62岁男性出现嗜酸性肉芽肿性多血管炎（EGPA，又称Churg-Strauss综合征）的典型症状和体征——多发性单神经炎、可触及的紫癜、嗜酸性粒细胞增多、核周型抗中性粒细胞胞浆抗体（P-ANCA）阳性，随后发生弥漫性肺泡出血。该患者长期存在轻度低钠血症，但后来出现了抗利尿激素分泌不当综合征的中度且有症状的低钠血症。在针对EGPA开始治疗后，患者的血清钠恢复到基线水平——轻度低钠血症。