Melo Carolina M, Cardoso Jéssica F, Perasoli Fernanda B, Marques Maria Betânia F, Mussel Wagner N, Moura Sandra A L, Da Silva Gisele R
School of Pharmacy, Federal University of São João del-Rei, Divinópolis, Minas Gerais, Brazil.
School of Pharmacy, Federal University of Ouro Preto, Ouro Preto, Minas Gerais, Brazil.
Data Brief. 2020 Mar 5;29:105311. doi: 10.1016/j.dib.2020.105311. eCollection 2020 Apr.
Data described in this article are related to the research article entitled "Amphotericin B-loaded Eudragit RL100 nanoparticles coated with hyaluronic acid (AMP EUD nanoparticles/HA) for the treatment of vulvovaginal candidiasis" [1]. In this work, we report original data on the statistical experimental design to formulate uncoated AMP EUD nanoparticles, data on the validation of spectrophotometric method to quantify the AMP released from uncoated EUD nanoparticles and coated with HA to obtain the drug release profiles as well as the drug encapsulation efficiency. In addition, we describe original data on characterization, including diameter size, polydispersity index, zeta potential, FTIR, DSC/TG, and XRD; data on diameter of inhibition halos of ; and on the vaginal burden of infected animals treated with uncoated AMP EUD nanoparticles and AMP EUD nanoparticles/HA. Finally, different histological sections of endocervix collected from treated and untreated animals were inserted into this manuscript.
本文所述数据与题为“负载两性霉素B的透明质酸包衣的Eudragit RL100纳米颗粒（AMP EUD纳米颗粒/HA）用于治疗外阴阴道念珠菌病”的研究文章相关[1]。在这项工作中，我们报告了关于制备未包衣的AMP EUD纳米颗粒的统计实验设计的原始数据、用于量化从未包衣的EUD纳米颗粒和包衣有HA的纳米颗粒中释放的AMP以获得药物释放曲线以及药物包封率的分光光度法验证数据。此外，我们描述了关于表征的原始数据，包括直径大小、多分散指数、zeta电位、傅里叶变换红外光谱（FTIR）、差示扫描量热法/热重分析法（DSC/TG）和X射线衍射（XRD）；关于抑菌圈直径的数据；以及关于用未包衣的AMP EUD纳米颗粒和AMP EUD纳米颗粒/HA治疗的感染动物的阴道负荷的数据。最后，将从治疗和未治疗动物收集的子宫颈不同组织切片插入本手稿。
