Department of Neurology, University of Florida College of Medicine, McKnight Brain Institute, Gainesville, Florida.
Department of Molecular Genetics & Microbiology, Center for NeuroGenetics, UF Genetics Institute, University of Florida College of Medicine, Gainesville, Florida.
Muscle Nerve. 2020 Sep;62(3):309-320. doi: 10.1002/mus.26866. Epub 2020 Apr 10.
Myotonic dystrophies (DM), the most common muscular dystrophies, are known to have significant sleep disturbances. We analyzed the literature on sleep and excessive daytime sleepiness (EDS) in DM over the past 30 years. In this review we provide a brief overview of sleep, sleep disorders, and methods of assessment. We also analyze data regarding major sleep disorders in DM patients, including: sleep-disordered breathing (SDB), with both central and obstructive sleep apneas (CSA,OSA); EDS; sleep-related movement disorders; and poor sleep quality. We review the possible pathogenesis of these disorders and outline management strategies. We also consider possible future avenues for research. The findings highlight the complex set of sleep-related problems, including the primary abnormality of sleep control in myotonic dystrophies. In individual patients the roles of poor sleep hygiene, SDB, primary hypersomnia, and excess fatigue require careful assessment for appropriate management.
肌强直性营养不良症（DM）是最常见的肌肉疾病，已知其存在明显的睡眠障碍。我们对过去 30 年来 DM 患者的睡眠和日间嗜睡（EDS）的文献进行了分析。在这篇综述中，我们简要概述了睡眠、睡眠障碍和评估方法。我们还分析了 DM 患者主要睡眠障碍的数据，包括：睡眠呼吸障碍（SDB），包括中枢性和阻塞性睡眠呼吸暂停（CSA、OSA）；EDS；与睡眠相关的运动障碍；以及睡眠质量差。我们回顾了这些障碍的可能发病机制，并概述了管理策略。我们还考虑了未来可能的研究方向。研究结果强调了与睡眠相关的一系列复杂问题，包括肌强直性营养不良症中睡眠控制的主要异常。在个别患者中，需要仔细评估睡眠卫生不佳、SDB、原发性嗜睡症和过度疲劳的情况，以确定适当的管理方法。
