三级新生儿重症监护病房治疗胎儿水肿活产新生儿的临床特征和新生儿结局。

Clinical characteristics and neonatal outcomes of liveborn newborns with hydrops fetalis treated in a tertiary level neonatal intensive care unit.

机构信息

Department of Neonatology, Necmettin Erbakan University, Meram Medical Faculty, Konya, Turkey.

Department of Neonatology, Van Training and Research Hospital, Health Sciences University, Van, Turkey.

出版信息

Birth Defects Res. 2020 Apr 1;112(6):515-522. doi: 10.1002/bdr2.1640.

DOI:10.1002/bdr2.1640

PMID:32212385

Abstract

BACKGROUND

This study was performed for examining the neonatal results and aetiological factors of neonates with hydrops fetalis (HF) and determining the factors affecting mortality.

METHODS

The medical records of liveborn neonates with HF who were admitted to a tertiary Neonatal Intensive Care Unit (NICU) in Konya, Turkey, between 2013 and 2019 were reviewed retrospectively. The demographic data, prenatal intervention, clinical findings, and results of the patients were recorded.

RESULTS

A total of 32.6% of the 46 liveborn HF infants had immune HF (IHF), while 67.4% had nonimmune HF (NIHF); there was prenatal diagnoses in 39 (84.7%) cases. Cordocentesis and blood transfusion (n = 14; 30.4%) were the prenatal diagnosis and treatment interventions with the highest rate. A total of 16 patients (34.7%) received in utero interventional treatment. It was determined that the mean gestational age was not associated with mortality; moreover, birthweight (BW), Apgar score and the need for mechanical ventilation affected mortality.

CONCLUSION

The prognosis changes according to different etiologies of HF. However, despite the developments in neonatal care, mortality is still high in HF infants.

摘要

背景

本研究旨在检查患有胎儿水肿（HF）的新生儿的新生儿结果和病因，并确定影响死亡率的因素。

方法

回顾性分析了 2013 年至 2019 年期间在土耳其科尼亚一家三级新生儿重症监护病房（NICU）住院的患有 HF 的活产新生儿的病历。记录了患者的人口统计学数据、产前干预、临床发现和结果。

结果

在 46 例活产 HF 婴儿中，有 32.6%为免疫性 HF（IHF），67.4%为非免疫性 HF（NIHF）；有 39 例（84.7%）存在产前诊断。有 14 例（30.4%）接受了脐带穿刺和输血（n = 14；30.4%）作为产前诊断和治疗干预措施，比例最高。共有 16 名患者（34.7%）接受了宫内介入治疗。确定胎龄与死亡率无关；此外，出生体重（BW）、阿普加评分和机械通气需求会影响死亡率。