Zhao Fan, Ye Miao-Yong, Zhao Jian-Feng, Lü Bo-Dong
The Second School of Clinical Medicine, Zhejiang University of Chinese Medicine, Hangzhou, Zhejiang 310053, China.
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Zhonghua Nan Ke Xue. 2018 Oct;24(10):927-932.
Erectile dysfunction (ED) is closely related with the phenotypic modulation of corporal cavernosum smooth muscle cells (CCSMC), a transitional tendency of CCSMCs switching from the contractile phenotype to the synthetic or proliferative phenotype. The molecular markers of contractile CCSMCs include α-SMA, SMMHC, Calponin, Smoothelin, and Desmin, while those of synthetic or proliferative CCSMCs involve Vimentin, Osteopontin, and Collagen I. Current studies show that phenotypic transformation of CCSMCs is related to the pathophysiological processes of different types of ED, such as bilateral cavernous nerve injury-induced ED, diabetes mellitus-associated ED, arterial ED, hypertension-associated ED, and so on. In addition, such external factors as hypoxia, platelet-derived growth factor, and tobacco combustion gas may directly affect rats or CCSMCs and consequently lead to phenotypic conversion of CCSMCs. This article presents a systematic review of the studies on the correlation of phenotypic transition of CCSMCs with ED.
勃起功能障碍（ED）与阴茎海绵体平滑肌细胞（CCSMC）的表型调节密切相关，即CCSMC从收缩表型向合成或增殖表型转变的一种过渡趋势。收缩性CCSMC的分子标志物包括α-平滑肌肌动蛋白（α-SMA）、平滑肌肌球蛋白重链（SMMHC）、钙调蛋白、平滑肌蛋白和结蛋白，而合成或增殖性CCSMC的分子标志物则涉及波形蛋白、骨桥蛋白和Ⅰ型胶原蛋白。目前的研究表明，CCSMC的表型转化与不同类型ED的病理生理过程有关，如双侧海绵体神经损伤所致ED、糖尿病相关性ED、动脉性ED、高血压相关性ED等。此外，低氧、血小板衍生生长因子和烟草燃烧气体等外部因素可能直接影响大鼠或CCSMC，进而导致CCSMC的表型转化。本文对CCSMC表型转变与ED相关性的研究进行系统综述。
