DNA 甲基转移酶 1 相互作用蛋白，作为肺癌的诊断和预后标志物。

, a Regulator of Methylation, as a Diagnostic and Prognostic Marker for Lung Cancer.

机构信息

Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.

出版信息

Cancer Invest. 2020 Apr;38(4):240-249. doi: 10.1080/07357907.2020.1747483. Epub 2020 Apr 16.

DOI:10.1080/07357907.2020.1747483

PMID:32212938

Abstract

We evaluated the value of , a regulator of methylation, as a biomarker for lung cancer. is expressed at higher levels in both lung adenocarcinoma (AD) and squamous cell carcinoma (SQ); however, a meta-analysis showed that expression is correlated with worse survival in patients with AD but not in those with SQ. knockdown suppressed the growth of lung cancer cell lines through G1 cell cycle arrest in some cell lines. These results suggest that may server as a diagnostic marker for AD and SQ and as a prognostic marker for AD in lung cancer.

摘要

我们评估了作为肺癌生物标志物的，一种甲基化调节剂的价值。在肺腺癌 (AD) 和鳞状细胞癌 (SQ) 中均表达水平较高；然而，荟萃分析显示，在 AD 患者中，表达与生存率降低相关，但在 SQ 患者中则不然。在某些细胞系中，通过 G1 细胞周期阻滞抑制肺癌细胞系的生长。这些结果表明，可能作为肺癌中 AD 和 SQ 的诊断标志物以及 AD 的预后标志物。