Chateau Thomas, Peyrin-Biroulet Laurent
FDepartment of Hepato-Gastroenterology, University Hospital of Grenoble, University of Grenoble Alpes, Grenoble, France.
FDepartment of Gastroenterology and Inserm NGERE, University Hospital of Nancy, University of Lorraine, Vandoeuvre-lès-Nancy, France.
United European Gastroenterol J. 2020 Mar;8(2):133-139. doi: 10.1177/2050640619887316. Epub 2019 Nov 4.
The main objectives in Crohn's disease are to avoid disease complications and preserve the patient's quality of life. Early disease control and close monitoring with specific targets to reach might be the only way to change the disease course. In two decades, we have moved from clinical response to full remission (clinical and endoscopic remission) requiring a tight monitoring of both symptoms and objective signs of inflammation. This review summarizes the concepts of tight control and treat-to-target and their potential for disease modification.
克罗恩病的主要目标是避免疾病并发症并维持患者的生活质量。早期疾病控制以及针对特定目标进行密切监测可能是改变疾病进程的唯一途径。在过去二十年中，我们已经从关注临床反应转变为追求完全缓解（临床和内镜下缓解），这需要对症状和炎症客观体征进行严格监测。本综述总结了严格控制和达标治疗的概念及其改变疾病的潜力。
