Department of Urology, Peking University First Hospital and Institute of Urology, Peking University, National Urological Cancer Center, Beijing, China.
Department of Anesthesiology, Peking University First Hospital, Peking University, Beijing, China.
Int Braz J Urol. 2020 Jul-Aug;46(4):585-598. doi: 10.1590/S1677-5538.IBJU.2019.0228. Epub 2020 Mar 15.
To explore the prognostic value of obesity (measured by BMI) on RCC in a systemic inflammation state.
Clinicopathological and hematological data of 540 surgically treated Chinese localized RCC patients between 2005 and 2010 were retrospectively collected. Found by receiver operating characteristic (ROC) curve for cancer-specific survival (CSS), the optimal cutoff values of neutrophil-lymphocyte ratio (NLR, an indicator of systemic inflammation state) and BMI were 2.12 and 23.32, respectively. Survival curves were drawn using Kaplan-Meier method. Univariate and multivariate Cox regression analyses were used to evaluate the prognostic value of BMI in localized RCC patients with different NLR.
Overall, 36 patients died with a median follow-up of 70 months. Median overall survival (OS) was 66 months and the 5-year OS rate was 92.7%. In the multivariate analysis of total patients, higher BMI was an independent protective factor for CSS in total patients (p=0.048). While in systemic inflammation subgroup (high NLR subgroup) patients, higher BMI (obesity) turned out to be an independent protective factor for both CSS (p=0.025) and RFS (p=0.048).
In localized RCC patients, obesity was an independent protective factor for CSS and RFS in a systemic inflammation state. Available at. https://www.intbrazjurol.com.br/pdf/aop/2019-0228OA.pdf.
探讨全身性炎症状态下肥胖（通过 BMI 衡量）对肾细胞癌的预后价值。
回顾性收集了 2005 年至 2010 年间 540 例接受手术治疗的中国局限性肾细胞癌患者的临床病理和血液学数据。通过接收者操作特征（ROC）曲线确定了用于癌症特异性生存（CSS）的中性粒细胞-淋巴细胞比值（NLR，全身性炎症状态的指标）和 BMI 的最佳截断值分别为 2.12 和 23.32。使用 Kaplan-Meier 方法绘制生存曲线。使用单变量和多变量 Cox 回归分析评估 BMI 在不同 NLR 的局限性 RCC 患者中的预后价值。
总体而言，36 例患者死亡，中位随访时间为 70 个月。中位总生存期（OS）为 66 个月，5 年 OS 率为 92.7%。在所有患者的多变量分析中，较高的 BMI 是所有患者 CSS 的独立保护因素（p=0.048）。然而，在全身性炎症亚组（高 NLR 亚组）患者中，较高的 BMI（肥胖）被证明是 CSS（p=0.025）和 RFS（p=0.048）的独立保护因素。
在局限性 RCC 患者中，肥胖是全身性炎症状态下 CSS 和 RFS 的独立保护因素。可在. https://www.intbrazjurol.com.br/pdf/aop/2019-0228OA.pdf 查看全文。
