5-氨基酮戊酸：恶性胶质瘤荧光引导切除术的陷阱及在恶性胶质瘤治疗中的应用
5-Aminolevulinic Acid: Pitfalls of Fluorescence-guided Resection for Malignant Gliomas and Application for Malignant Glioma Therapy.
作者信息
Yamamoto Junkoh, Kitagawa Takehiro, Miyaoka Ryo, Suzuki Kohei, Takamatsu Seishiro, Saito Takeshi, Nakano Yoshiteru
机构信息
Department of Neurosurgery, University of Occupational and Environmental Health, Japan.
出版信息
J UOEH. 2020;42(1):27-34. doi: 10.7888/juoeh.42.27.
5-Aminolevulinic acid (ALA) has been widely used as an intravital fluorescence marker in the fluorescence-guided resection of malignant gliomas. Although not a photosensitizer itself, 5-ALA is a prodrug that accumulates protoporphyrin IX (PpIX) in the mitochondria of glioma cells; PpIX acts as a photosensitizer. Fluorescence-guided resection for malignant gliomas has some pitfalls. Moreover, 5-ALA is not merely a fluorescence marker but has potential as a mitochondria-targeting drug for malignant glioma therapy. In this article, we review the literature related to 5-ALA, discuss the pitfalls of fluorescence-guided resection using 5-ALA for malignant gliomas, and describe the application of 5-ALA for malignant glioma therapy with personal opinions.
5-氨基乙酰丙酸（ALA）已被广泛用作恶性胶质瘤荧光引导切除术中的活体荧光标记物。尽管5-ALA本身不是光敏剂，但它是一种前药，可在胶质瘤细胞的线粒体中积累原卟啉IX（PpIX）；PpIX充当光敏剂。恶性胶质瘤的荧光引导切除存在一些缺陷。此外，5-ALA不仅是一种荧光标记物，还具有作为恶性胶质瘤治疗的线粒体靶向药物的潜力。在本文中，我们回顾了与5-ALA相关的文献，讨论了使用5-ALA进行恶性胶质瘤荧光引导切除的缺陷，并阐述了5-ALA在恶性胶质瘤治疗中的应用及个人观点。
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