22q11.2 缺失综合征患者低剂量阿立哌唑治疗精神症状的疗效。
Efficacy of Low-Dose Aripiprazole for Treatment of Psychotic Symptoms in a Patient with 22q11.2 Deletion Syndrome.
机构信息
Kontoangelos, Economou, Papageorgiou, 1st Department of Psychiatry, Eginition Hospital, School of Medicine, University of Athens, University Mental Health Research Institute, Athens, Greece. Lazaratou, 1st Department of Psychiatry, Eginition Hospital, School of Medicine, University of Athens, Athens, Greece. Yiannopoulou, Neurological Department, Henry Dunant Hospital Center, Athens, Greece.
出版信息
Psychopharmacol Bull. 2020 Mar 12;50(1):35-39.
OBJECTIVES
The 22q11.2 deletion syndrome is one of the most prevalent genetic disorders and children suffering from this syndrome have been found to have a substantially greater risk for the development of schizophrenia and bipolar disorder. Psychiatric medications such as antipsychotics are commonly used in individuals with 22q11.2DS.
EXPERIMENTAL DESIGN
This is a case of 13 years male young man suffering from 22q11.2 deletion syndrome. Since adolescence, he presented with behavioural disorders, aggression, verbal abuse, sleep disorders.
PRINCIPAL OBSERVATIONS
The psychiatric examination confirmed the delusional idea, which was repeated in an obsessive way. There were also auditory hallucinations along with reference ideas. Aripiprazole was administered in 8 mg daily which gave more spectacular results and was better tolerated.
CONCLUSIONS
In the present situation delusional ideas are no longer mentioned, but a cognitive deduction is found. Aripiprazole can be an effective pharmacological solution for the psychotic symptoms in patients suffering from 22q11DS.
目的
22q11.2 缺失综合征是最常见的遗传疾病之一，患有这种综合征的儿童患精神分裂症和双相情感障碍的风险大大增加。抗精神病药等精神药物通常用于 22q11.2DS 患者。
实验设计
这是一名 13 岁男性少年患有 22q11.2 缺失综合征。自青春期以来，他出现了行为障碍、攻击性、言语虐待、睡眠障碍。
主要观察结果
精神检查证实了妄想观念，这种观念以一种强迫性的方式反复出现。他还出现了幻听和参照观念。给予每日 8 毫克的阿立哌唑，结果更显著，且耐受性更好。
结论
目前，妄想观念已不再提及，但发现存在认知推断。阿立哌唑可以为 22q11DS 患者的精神病症状提供有效的药物治疗方案。
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