Zhang Zhi-Bing, Wang Heng-Qi, Zhang Ling
School of Public Health, Wuhan University of Science and Technology, Hubei Province Key Laboratory for Occupational Hazard Identification and Control, Wuhan, Hubei 430065, China.
Zhonghua Nan Ke Xue. 2019 Mar;25(3):195-201.
Intra flagellar transport (IFT) is an evolutionarily conserved mechanism thought to be essential for the assembly and maintenance of most eukaryotic cilia and flagella. Development of the sperm tail axoneme resembles the cilia formation, which is organized by intraflagellar transport (IFT). Of all mammalian cells, sperm have the longest motile cilia, but few studies are reported on the role of IFT in the formation of sperm flagella and the mechanisms of IFT in spermiogenesis. This article focuses on the role of IFT in spermatogenesis and the importance of IFT in male fertility.
鞭毛内运输（IFT）是一种进化上保守的机制，被认为对大多数真核生物的纤毛和鞭毛的组装和维持至关重要。精子尾部轴丝的发育类似于纤毛形成，由鞭毛内运输（IFT）组织。在所有哺乳动物细胞中，精子具有最长的能动纤毛，但关于IFT在精子鞭毛形成中的作用以及IFT在精子发生中的机制的研究报道较少。本文重点关注IFT在精子发生中的作用以及IFT在男性生育中的重要性。
