Department of Pediatrics, Putuo Hospital of Traditional Chinese Medicine, East of Second Floor Ward, 19 Wenkang Street, Putuo District, Zhoushan, Zhejiang 316100, China.
Department of Pediatrics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Curr Pharm Biotechnol. 2021;22(1):159-167. doi: 10.2174/1389201021666200327163322.
Tripterine (TRI), an active monomer in Tripterygium wilfordii, has significant pharmacological activities, such as anti-inflammatory, immunosuppressive and anti-tumor activities. TRI may be used to treat allergic diseases because of its characteristics of immunosuppression.
This study aims to explore the anti-allergic effect of TRI.
It was tested in vivo and in vitro in this study.
The results showed that TRI could significantly inhibit histamine release from rat peritoneal mast cells; the inhibitory effect of TRI on histamine release was stronger than that of other known histamine inhibitors such as disodium cromoglyceride. TRI also significantly inhibited systemic anaphylactic shock induced by compound 48/80 and skin allergy induced by IgE, and inhibited the expression of inflammatory factors secreted by Human Mast Cells (HMC-1) induced by Phorbol 12-Myristate 13- Acetate (PMA) and calcium carrier A23187. In the animal model of allergic rhinitis induced by Ovalbumin (OA), the scores of friction, histamine, IgE, inflammatory factors and inflammatory cells decreased after TRI was administered orally or nasally.
TRI, as an active immunoregulatory factor, has great potential in the treatment of mast cell-mediated allergic diseases.
雷公藤红素（TRI）是雷公藤中的一种活性单体，具有显著的药理活性，如抗炎、免疫抑制和抗肿瘤活性。由于其免疫抑制特性，TRI 可能用于治疗过敏疾病。
本研究旨在探讨 TRI 的抗过敏作用。
本研究进行了体内和体外试验。
结果表明，TRI 可显著抑制大鼠腹腔肥大细胞释放组胺；TRI 对组胺释放的抑制作用强于其他已知的组胺抑制剂，如二钠色甘酸钠。TRI 还显著抑制了由化合物 48/80 诱导的全身性过敏休克和由 IgE 诱导的皮肤过敏，并抑制了 Phorbol 12-Myristate 13-Acetate（PMA）和钙载体 A23187 诱导的人肥大细胞（HMC-1）分泌的炎症因子的表达。在卵清蛋白（OA）诱导的变应性鼻炎动物模型中，TRI 经口服或鼻内给药后，摩擦、组胺、IgE、炎症因子和炎症细胞的评分均降低。
作为一种活性免疫调节因子，TRI 在治疗肥大细胞介导的过敏疾病方面具有巨大潜力。
