Pathogenic Microbe Laboratory, Research Institute, National Center for Global Health and Medicine, 1-21-1, Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan.
Disease Control and Prevention Center, National Center for Global Health and Medicine, 1-21-1, Toyama, Shinjuku-ku, Tokyo 162-8655, Japan.
J Med Microbiol. 2020 Apr;69(4):530-536. doi: 10.1099/jmm.0.001175.
Little is known about the epidemiology of strains producing a carbapenemase or metallo-beta-lactamase in Vietnamese hospitals. This study analysed strains resistant to imipenem or meropenem that had been isolated from patients admitted to one of the largest hospitals in Vietnam in 2014-2017. Eighteen Vietnamese (VN) strains were subjected to whole-genome sequencing and their sequences compared with those of 17 strains carrying a carbapenemase or metallo-beta-lactamase in the database (db strains). Although the distribution of virulence factors did not differ significantly between VN and db strains, all 18 VN isolates harboured , phylogenetic analysis revealed a high clonality of the VN strains. Bayesian phylogenetic analysis suggested that the VN strains speciated relatively recently. Several prevalent clones of carbapenem-resistant have circulated within Vietnamese hospitals. Adequate measures are needed to prevent their further spread.
关于越南医院中产碳青霉烯酶或金属β-内酰胺酶的 菌株的流行病学情况知之甚少。本研究分析了 2014-2017 年从越南一家最大医院住院患者中分离出的对亚胺培南或美罗培南耐药的 菌株。对 18 株越南（VN） 株进行全基因组测序，并将其序列与数据库中 17 株携带碳青霉烯酶或金属β-内酰胺酶的 株（db 株）进行比较。尽管 VN 株和 db 株之间毒力因子的分布没有显著差异，但所有 18 株 VN 分离株均携带 ，系统发育分析显示 VN 株具有较高的克隆性。贝叶斯系统发育分析表明，VN 株相对较近才出现种系分化。耐碳青霉烯类 中的几种流行克隆在越南医院内传播。需要采取适当措施防止其进一步传播。
