Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
J Pediatr Hematol Oncol. 2021 Apr 1;43(3):e380-e384. doi: 10.1097/MPH.0000000000001781.
Although outcomes for children with B-cell non-Hodgkin lymphoma are excellent, between 20% and 40% demonstrate residual radiologic abnormalities at disease assessment during consolidation therapy, the significance of which remains uncertain. The authors report the outcomes for all children treated for B-cell non-Hodgkin lymphoma at our center over an 11-year period. Twenty-four of 64 (38%) children had residual radiologic abnormalities at disease remission assessment. Seven (29%) underwent histologic biopsies that were normal. No children with residual radiologic abnormalities experienced disease relapse or death, suggesting that imaging at this time point creates clinical uncertainty without indicating residual disease or predicting relapse.
虽然儿童 B 细胞非霍奇金淋巴瘤的治疗效果很好，但在巩固治疗期间疾病评估时，仍有 20%至 40%的患儿存在残留的影像学异常，但其意义仍不确定。作者报告了在过去 11 年中在他们中心接受 B 细胞非霍奇金淋巴瘤治疗的所有儿童的结果。在疾病缓解评估时，64 名儿童中有 24 名（38%）存在残留的影像学异常。其中 7 名（29%）接受了组织学活检，结果正常。没有残留影像学异常的患儿出现疾病复发或死亡，这表明此时的影像学检查会造成临床不确定性，而不能提示残留疾病或预测复发。
