Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305-8572, Japan.
Department of Pharmacognosy, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi, 981-8558, Japan.
J Nat Med. 2020 Jun;74(3):579-583. doi: 10.1007/s11418-020-01398-6. Epub 2020 Mar 26.
The number of patients with Alzheimer's disease (AD) and type 2 diabetes (T2D) is increasing rapidly, and thus more research has been focused on the relationship between these two age-related chronic diseases. According to the amyloid hypothesis, prevention of the aggregation of amyloid β (Aβ) and human islet amyloid polypeptide (hIAPP) is a promising strategy for AD and T2D. In this study, thioflavin-T assay and transmission electron microscopy were performed to evaluate the inhibitory effect of three phenylpropanoids isolated from Lycopus lucidus-schizotenuin A and lycopic acids A and B-on both Aβ and hIAPP fibrillization. All tested compounds exhibited similarly strong inhibitory activity toward amyloid aggregation. These results suggested that catechol moieties play important roles in the inhibition of amyloid plaque formation.
阿尔茨海默病（AD）和 2 型糖尿病（T2D）患者的数量正在迅速增加，因此更多的研究集中在这两种与年龄相关的慢性疾病之间的关系上。根据淀粉样蛋白假说，预防淀粉样蛋白 β（Aβ）和人胰岛淀粉样多肽（hIAPP）的聚集是 AD 和 T2D 的一种有前途的策略。在这项研究中，使用噻唑蓝-T 测定法和透射电子显微镜来评估从糙叶败酱 Lycopus lucidus-schizotenuin A 和糙叶败酱酸 A 和 B 中分离得到的三种苯丙素对 Aβ和 hIAPP 纤维形成的抑制作用。所有测试的化合物对淀粉样蛋白聚集均表现出相似的强抑制活性。这些结果表明儿茶酚结构在抑制淀粉样斑块形成中起着重要作用。
