Sarkar D K
Department of Reproductive Medicine, University of California, San Diego, La Jolla.
Neuroendocrinology. 1988 Aug;48(2):214-6. doi: 10.1159/000125012.
Recent studies have demonstrated that oxytocin (OT) stimulates prolactin (PRL) release from the anterior pituitary gland and that the secretion of OT into pituitary portal blood changes during the rat estrous cycle. To better define the role of OT on PRL release during the reproductive cycle, the effect of administration of antiserum specific for OT on preovulatory PRL secretion in female rats was studied. Intravenous injection of OT antiserum into cyclic female rats between 13.30 and 14.00 h of proestrus neutralized the elevated levels of OT in pituitary portal blood and significantly reduced the subsequent PRL surge. The characteristic proestrous surge of luteinizing hormone (LH) was not affected by the OT antiserum treatment. These data support a physiological role for OT in the regulation of PRL release during the reproductive cycle.
最近的研究表明，催产素（OT）可刺激垂体前叶释放催乳素（PRL），并且在大鼠发情周期中，OT分泌到垂体门脉血中的情况会发生变化。为了更好地确定OT在生殖周期中对PRL释放的作用，研究了给予OT特异性抗血清对雌性大鼠排卵前PRL分泌的影响。在发情前期的13:30至14:00之间，向处于发情周期的雌性大鼠静脉注射OT抗血清，可中和垂体门脉血中升高的OT水平，并显著降低随后的PRL激增。促黄体生成素（LH）典型的发情前期激增不受OT抗血清处理的影响。这些数据支持了OT在生殖周期中调节PRL释放的生理作用。
