Yan Cai-Xia, Li Jia, Shen Xin, Luo Li, Li Yan, Li Ming-Yuan
State Key Laboratory of Oral Diseases , National Clinical Research Center for Oral Diseases，West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Chengdu Institute of Biological Products, Chengdu 610023, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2020 Mar;51(2):139-145. doi: 10.12182/20200360506.
Coronavirus disease 2019 (COVID-19) caused by the novel coronavirus, also known as severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), has become a Public Health Emergency of International Concern. Due to the large infection population, broad transmissibility and high mortality, it is urgent to find out the efficient and specific methods to prevent and treat COVID-19. As biological products have broadly applied in the prevention and treatment of severe epidemic diseases, they are promising in blocking novel coronavirus infection. According to the research advances of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), we reviewed the potential application of biological products such as interferon, convalescent plasma, intestinal micro-ecological regulators, vaccines and therapeutic antibodies, etc. , on prevention and treatment of COVID-19. May this review be helpful for conquering COVID-19 in the near future.
由新型冠状病毒引起的2019冠状病毒病（COVID-19），也称为严重急性呼吸综合征冠状病毒2（SARS-CoV-2），已成为国际关注的突发公共卫生事件。由于感染人群庞大、传播性广和死亡率高，迫切需要找到有效且特异的方法来预防和治疗COVID-19。由于生物制品已广泛应用于严重流行病的预防和治疗，它们在阻断新型冠状病毒感染方面很有前景。根据严重急性呼吸综合征（SARS）和中东呼吸综合征（MERS）的研究进展，我们综述了干扰素、康复期血浆、肠道微生态调节剂、疫苗和治疗性抗体等生物制品在COVID-19预防和治疗中的潜在应用。愿本综述有助于在不久的将来攻克COVID-19。
