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肝移植术后第一周内动脉并发症的血管内治疗

Endovascular Therapy of Arterial Complications Within the First Week After Liver Transplant.

作者信息

Gastaca Mikel, Gomez Javier, Terreros Ignacio, Izquierdo Javier, Ruiz Patricia, Prieto Mikel, Ventoso Alberto, Palomares Ibone, Aguinaga Alexander, Valdivieso Andrés

机构信息

Biocruces Bizkaia Health Research Institute. Liver Transplantation Unit, Hospital Universitario Cruces, Bilbao, Spain; University of the Basque Country, Bilbao, Spain.

Servicio de Cirugía General y Aparato Digestivo, Hospital Universitario San Cecilio, Granada, Spain.

出版信息

Transplant Proc. 2020 Jun;52(5):1464-1467. doi: 10.1016/j.transproceed.2020.02.075. Epub 2020 Mar 25.

Abstract

BACKGROUND

Recent radiologic advances have made endovascular treatment a very successful option for arterial complications after liver transplant. This article presents our experience of using endovascular treatments during the first week after liver transplant.

METHODS

This study is a retrospective, single-center analysis. Liver transplants performed between 2010 and 2018 were analyzed. All patients underwent Doppler ultrasonography on days 1 and 7. Endovascular therapy was indicated in hepatic artery thrombosis diagnosed early after transplant and in stenosis when hepatic narrowing was > 70%. Patients were treated with subcutaneous anticoagulant therapy and with antiplatelet agents after endovascular therapy.

RESULTS

Seven patients (1.1%) were included in the study. Stenosis was the reason in 5 patients while 2 patients had symptoms of thrombosis. The first 2 patients were initially treated with angioplasty; both had restenosis and were treated with angioplasty and stent placement, respectively. The 5 most recent patients received stenting as a primary treatment. Two of these patients developed a new stenosis. No patient developed any hepatic artery complication related to the procedure, and only 1 patient experienced a postprocedure complication (femoral artery pseudoaneurysm), which was managed conservatively. No patient required retransplant. After a median follow-up of 48 months (range, 35-85 months) 1 patient had died, and the rest were alive and asymptomatic.

CONCLUSIONS

Although there is scant experience of the use of endovascular therapy very shortly after liver transplant, recent advances in interventional radiology have made the technique feasible and safe, and it achieves a high success rate.

摘要

背景

近期放射学进展使血管内治疗成为肝移植术后动脉并发症非常成功的治疗选择。本文介绍了我们在肝移植术后第一周使用血管内治疗的经验。

方法

本研究为回顾性单中心分析。对2010年至2018年期间进行的肝移植进行分析。所有患者在第1天和第7天接受多普勒超声检查。对于移植后早期诊断的肝动脉血栓形成以及肝动脉狭窄>70%的情况,均采用血管内治疗。血管内治疗后,患者接受皮下抗凝治疗和抗血小板药物治疗。

结果

7例患者(1.1%)纳入研究。5例患者的病因是狭窄,2例患者有血栓形成症状。前2例患者最初接受血管成形术治疗;二者均出现再狭窄,分别接受了血管成形术和支架置入术治疗。最近的5例患者接受支架置入术作为初始治疗。其中2例患者出现新的狭窄。没有患者发生与手术相关的肝动脉并发症,只有1例患者出现术后并发症(股动脉假性动脉瘤),经保守治疗处理。没有患者需要再次移植。中位随访48个月(范围35 - 85个月)后,1例患者死亡,其余患者存活且无症状。

结论

尽管肝移植后不久使用血管内治疗的经验较少,但介入放射学的最新进展使该技术可行且安全,并且成功率很高。

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