Department of Surgery, Division of Surgical Oncology and Endocrine Surgery, Mayo Clinic Arizona, Phoenix, AZ, USA.
Mayo Clinic School of Medicine, Phoenix, AZ, USA.
Ann Surg Oncol. 2020 Sep;27(9):3436-3445. doi: 10.1245/s10434-020-08386-w. Epub 2020 Mar 27.
Enhanced recovery after surgery (ERAS) principles have been beneficial in major abdominal surgery. ERAS was instituted in our breast surgery practice in 2017. The goal of this study was to evaluate the feasibility of outpatient mastectomies before and after ERAS.
A retrospective review of all mastectomies between 1/2013 and 6/2018 was performed. Patients receiving autologous flap reconstruction were excluded. The institution-specific ERAS pathway began on February 1, 2017. Patient characteristics, operative intervention, and postoperative outcomes were compared between pre-ERAS and post-ERAS groups and between outpatient and inpatient subgroups. Continuous and categorical variables were compared using Wilcoxon rank-sum and Chi-square analyses.
A total of 487 patients were analyzed. Three hundred and forty-seven (71%) were prior to ERAS and 140 after (29%). The two groups were not significantly different in background characteristics. Same-day discharge occurred in 58.6% of post-ERAS patients versus 7.2% of pre-ERAS patients (p < 0.001). Liposomal bupivacaine block was used for pain control more in the post-ERAS group, 62.1% versus 6.1% (p < 0.001). Reconstruction type differed with 45.7% of the post-ERAS group undergoing direct-to-implant reconstruction versus 34.3% of pre-ERAS patients (p < 0.001) and with higher rates of submuscular implant and tissue expander placement in the pre-ERAS versus post-ERAS group (p < 0.001). Complications rates were lower in the post-ERAS group versus pre-ERAS group, 32.9% versus 52.4% (p < 0.001). The outpatient subgroup had higher rates of liposomal bupivacaine administration 74.4% versus 44.8% (p < 0.001). Baseline characteristics and complication rates did not differ between outpatient and admitted subgroups.
ERAS principles can be applied to breast cancer patients and allow for outpatient mastectomies with no increase in postoperative morbidity.
加速康复外科(ERAS)原则在大型腹部手术中已被证明是有益的。我们的乳腺外科实践于 2017 年开始实施 ERAS。本研究的目的是评估 ERAS 实施前后门诊乳房切除术的可行性。
对 2013 年 1 月至 2018 年 6 月期间所有乳房切除术患者进行回顾性研究。排除接受自体皮瓣重建的患者。该机构特定的 ERAS 方案于 2017 年 2 月 1 日开始实施。比较 ERAS 实施前后组和门诊与住院亚组之间的患者特征、手术干预和术后结局。使用 Wilcoxon 秩和检验和卡方检验比较连续和分类变量。
共分析了 487 例患者。347 例(71%)在 ERAS 实施前,140 例(29%)在 ERAS 实施后。两组在背景特征上无显著差异。ERAS 实施后组的患者中,58.6%可当日出院,而 ERAS 实施前组仅为 7.2%(p<0.001)。在 ERAS 实施后组中,更多地使用了脂质体布比卡因阻滞来控制疼痛,占 62.1%,而 ERAS 实施前组仅占 6.1%(p<0.001)。重建类型也有所不同,ERAS 实施后组中有 45.7%的患者行直接植入物重建,而 ERAS 实施前组为 34.3%(p<0.001),且 ERAS 实施后组中肌下植入物和组织扩张器的放置率更高,而 ERAS 实施前组则较低(p<0.001)。ERAS 实施后组的并发症发生率低于 ERAS 实施前组,分别为 32.9%和 52.4%(p<0.001)。门诊亚组中,脂质体布比卡因使用率更高,为 74.4%,而住院亚组为 44.8%(p<0.001)。门诊和住院亚组之间的基线特征和并发症发生率无差异。
ERAS 原则可应用于乳腺癌患者,使门诊乳房切除术成为可能,且不会增加术后发病率。