López Gordo Sandra, Jimeno-Fraile Jaime, García-Monferrer Anna, Nicolau Pau, Ruiz-Edo Neus, Ramirez-Maldonado Elena, Rojas Santiago, Serra-Serra Cristina
General and Digestive Surgery Department, Maresme Health Consortium (Mataró Hospital), 08304 Mataró, Spain.
Unit of Human Anatomy and Embriology, Department of Morphological Sciences, Faculty of Medicine, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Spain.
Cancers (Basel). 2025 Jun 30;17(13):2201. doi: 10.3390/cancers17132201.
Axillary lymph node dissection (ALND), although increasingly less necessary, is still required in specific breast cancer surgery scenarios, such as cases with a high axillary tumor burden. However, traditional practices are being reassessed due to the associated morbidity and impacts on recovery. This review explores five critical and controversial innovations in ALND: (1) same-day discharge, (2) omission of surgical drains, (3) application of fibrin sealants, (4) minimally invasive techniques, and (5) their collective influence on quality of life (QoL). Same-day discharge has proven to be safe and cost-effective, increasing patient satisfaction without raising complication rates. The omission of drains, while slightly increasing seroma volumes, is linked to shorter hospital stays and fewer complications. The use of fibrin sealants shows promising results in reducing the seroma volume and duration, expediting recovery, although their routine use remains under debate. Minimally invasive and endoscopic techniques reduce morbidity and improve cosmetic outcomes while maintaining oncological safety. Quality of life (QoL) is essential in the evaluation of breast cancer treatment and is evaluated using tools such as EORTC QLQ-C30, QLQ-BR23, and FACT-B, SF-36, which assess physical, emotional, and psychosocial recovery. Innovations in ALND seem to improve QoL by minimizing pain, increasing arm function, and reducing psychological stress, underscoring the importance of patient-centered strategies. Although axillary lymphadenectomy increases arm morbidity compared to sentinel node biopsy, its overall impact on quality of life appears limited, likely due to the overlapping effects of systemic therapies and breast surgery.
腋窝淋巴结清扫术(ALND),尽管必要性日益降低,但在特定的乳腺癌手术场景中仍有必要,比如腋窝肿瘤负荷高的病例。然而,由于其相关的发病率以及对恢复的影响,传统做法正在重新评估。本综述探讨了腋窝淋巴结清扫术中五项关键且有争议的创新:(1)当日出院,(2)不放置手术引流管,(3)应用纤维蛋白封闭剂,(4)微创技术,以及(5)它们对生活质量(QoL)的综合影响。当日出院已被证明是安全且具有成本效益的,在不增加并发症发生率的情况下提高了患者满意度。不放置引流管,虽然血清肿体积略有增加,但与缩短住院时间和减少并发症有关。使用纤维蛋白封闭剂在减少血清肿体积和持续时间、加快恢复方面显示出有前景的结果,尽管其常规使用仍存在争议。微创和内镜技术在保持肿瘤学安全性的同时降低了发病率并改善了美容效果。生活质量(QoL)在乳腺癌治疗评估中至关重要,并使用诸如欧洲癌症研究与治疗组织核心生活质量问卷(EORTC QLQ-C30)、乳腺癌特异性问卷(QLQ-BR23)以及癌症治疗功能评价量表-乳腺癌(FACT-B)、健康调查简表(SF-36)等工具进行评估,这些工具可评估身体、情感和社会心理恢复情况。腋窝淋巴结清扫术中的创新似乎通过减轻疼痛、增加手臂功能和减轻心理压力来改善生活质量,突出了以患者为中心策略的重要性。尽管与前哨淋巴结活检相比,腋窝淋巴结清扫术增加了手臂发病率,但其对生活质量的总体影响似乎有限,这可能是由于全身治疗和乳房手术的重叠效应所致。