Spranger J
Children's Hospital, University of Mainz, FRG.
Pathol Immunopathol Res. 1988;7(1-2):76-80. doi: 10.1159/000157098.
Bone dysplasia families are recognized by distinct patterns of radiographic changes. These patterns are understood as manifestations of distinct pathogenetic processes. The concept is evident in dysostosis multiplex and in osteogenesis imperfecta and is hypothetical in other families. The concept may aid in the diagnostic classification and pathogenetic elucidation of individual bone dysplasias.
骨发育异常家族可通过X线改变的独特模式来识别。这些模式被理解为不同致病过程的表现。这一概念在多发性骨发育异常和成骨不全中很明显，在其他家族中则是假设性的。这一概念可能有助于个体骨发育异常的诊断分类和致病机制的阐明。
